| + |
CCN2 | up-regulates 
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277683 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33358571 |
As a matricellular protein, connective tissue growth factor (CTGF) functions beyond its classical role in extracellular matrix (ECM) remolding. Increasing evidence emphasizes the notion that CTGF is pivotal in cancer initiation and progression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCN2 | up-regulates activity 
binding
|
A5/b1 integrin |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277687 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32928643 |
CTGF is highly expressed in PDAC tissues, especially in tumor stroma (as shown by immunohistochemistry, CTGF: brown stain). The tumor cell-secreted CTGF promotes pancreatic stellate cell (PSC) proliferation, adhesion, and migration via integrin α5β1, leading to extracellular matrix (ECM) deposition.Pancreatic cancer cells secrete high levels of CTGF that binds to integrin α5β1, promoting PSC proliferation, adhesion, and migration |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TEAD4 | up-regulates quantity by expression
transcriptional regulation
|
CCN2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277686 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33358571 |
The multifunctional cytokine TGF-β has been identified as a potent inducer of CTGF expression, activating CTGF transcription through the canonical Smad signaling pathway. It is worth noting that TGF-β synergizes with Hippo–Yes-associated protein (YAP) signaling, a key regulator of tumorigenesis, to induce the expression of CTGF by the formation of a YAP-TEAD4-Smad3-p300 complex on the CTGF promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCN2 | up-regulates
binding
|
LRP6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178875 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18528331 |
Igfbp-4 physically interacted with a wnt receptor, frizzled 8 (frz8), and a wnt co-receptor, low-density lipoprotein receptor-related protein 6 (lrp6), and inhibited the binding of wnt3a to frz8 and lrp6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MZF1 | up-regulates quantity by expression
transcriptional regulation
|
CCN2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226307 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25899830 |
we report the regulation of the CTGF and NOV genes by Myeloid Zinc Finger-1 (MZF-1), a hematopoietic transcription factor. We show the interaction of MZF-1 with the CTGF and NOV promoters in several cell types. Up-regulation of MZF-1 via calcitriol and vitamin A induces expression of CTGF and NOV, implicating a role for these vitamins in the functions of these two genes. Lastly, knockdown of MZF1 reduces levels of CTGF and NOV. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NME1 | down-regulates quantity by repression 
transcriptional regulation
|
CCN2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255160 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17671192 |
To elucidate the molecular mechanism of Nm23-H1 motility suppression, expression microarray analysis of an MDA-MB-435 cancer cell line overexpressing wild-type Nm23-H1 was done and cross-compared with expression profiles from lines expressing the P96S and S120G mutants. Nine genes, MET, PTN, SMO, FZD1, L1CAM, MMP2, NETO2, CTGF, and EDG2, were down-regulated by wild-type but not by mutant Nm23-H1 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CCN2
- 
- 