Summary

Name HSD11B1
Full Name Corticosteroid 11-beta-dehydrogenase isozyme 1
Synonyms 11-beta-hydroxysteroid dehydrogenase 1, 11-DH, 11-beta-HSD1, Short chain dehydrogenase/reductase family 26C member 1 | HSD11, HSD11L, SDR26C1
Primary ID P28845
Links - -
Type protein
Relations 2
Function Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone (PubMed:10497248). Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation HSD11B1 0.278
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation HSD11B1 0.289
Publications: 1 Organism: Homo Sapiens