| + |
UBE2I | down-regulates activity 
sumoylation
|
CEBPA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256334 |
Lys161 |
ALRPLVIkQEPREED |
in vitro |
|
| pmid |
sentence |
| 12511558 |
C/EBPalpha interacts directly with the E2 SUMO-conjugating enzyme Ubc9 and can be SUMOylated in vitro using purified recombinant components. Our results indicate that SUMO modification of SC motifs provides a means to rapidly control higher order interactions among transcription factors and suggests that SUMOylation may be a general mechanism to limit transcriptional synergy. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MAPK1 | down-regulates
phosphorylation
|
CEBPA |
0.352 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-120566 |
Ser21 |
PMSSHLQsPPHAPSS |
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 14701740 |
Ccaat/enhancer-binding protein alpha (c/ebpalpha) is one of the key transcription factors that mediate lineage specification and differentiation of multipotent myeloid progenitors into mature granulocytes.Here we report that inducers of monocyte differentiation inhibit the alternate cell fate choice, that of granulopoiesis, through inhibition of c/ebpalpha. This inhibition is mediated by extracellular signal-regulated kinases 1 and/or 2 (erk1/2), which interact with c/ebpalpha through an fxfp docking site and phosphorylate serine 21. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKCD | down-regulates quantity by destabilization
phosphorylation
|
CEBPA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279427 |
Ser21 |
PMSSHLQsPPHAPSS |
Homo sapiens |
|
| pmid |
sentence |
| 23814099 |
We next demonstrated by immunoprecipitation that IL-32\u03b2 interacted with PKC\u03b4 and C/EBP\u03b1, thereby mediating C/EBP\u03b1 Ser-21 phosphorylation by PKC\u03b4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279426 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23473759 |
This pathway is triggered by activation of PKCdelta, and activated PKCdelta enhanced the phosphorylation of C/EBPalpha, which consequently led to its cytoplasmic translocation, transcriptional inactivation, ubiquitination and degradation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | down-regulates
phosphorylation
|
CEBPA |
0.371 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-120570 |
Ser21 |
PMSSHLQsPPHAPSS |
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 14701740 |
Ccaat/enhancer-binding protein alpha (c/ebpalpha) is one of the key transcription factors that mediate lineage specification and differentiation of multipotent myeloid progenitors into mature granulocytes.Here we report that inducers of monocyte differentiation inhibit the alternate cell fate choice, that of granulopoiesis, through inhibition of c/ebpalpha. This inhibition is mediated by extracellular signal-regulated kinases 1 and/or 2 (erk1/2), which interact with c/ebpalpha through an fxfp docking site and phosphorylate serine 21. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GSK3B | up-regulates activity 
phosphorylation
|
CEBPA |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251231 |
Thr226 |
HLQPGHPtPPPTPVP |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 10567568 |
Glycogen synthase kinase 3 (GSK3) phosphorylates T222 and T226, causing a conformational change in C/EBPα. GSK3-mediated phosphorylation does not, in itself, dramatically alter the activity of C/EBPα in our assays. phosphorylation of C/EBPalpha and other substrates by GSK3 may be required for adipogenesis, since treatment of differentiating preadipocytes with lithium inhibits their conversion to adipocytes. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251232 |
Thr230 |
GHPTPPPtPVPSPHP |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 10567568 |
Glycogen synthase kinase 3 (GSK3) phosphorylates T222 and T226, causing a conformational change in C/EBPα. GSK3-mediated phosphorylation does not, in itself, dramatically alter the activity of C/EBPα in our assays. phosphorylation of C/EBPalpha and other substrates by GSK3 may be required for adipogenesis, since treatment of differentiating preadipocytes with lithium inhibits their conversion to adipocytes. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis, Acute Myeloid Leukemia, AML_TRIPLETS, Triple mutant AML |
| + |
PCSK7 | down-regulates
phosphorylation
|
CEBPA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-186202 |
|
|
Homo sapiens |
Neutrophil |
| pmid |
sentence |
| 19544470 |
Addition of active p38a induced phosphorylation of wild-type c/ebp_? (c/ebp_?WT) on serine 21 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LEF1 | up-regulates quantity by expression 
transcriptional regulation
|
CEBPA |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254551 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19620402 |
We have identified LEF-1 as a decisive transcription factor in granulopoiesis controlling proliferation and granulocytic differentiation by direct activation of its target gene, C/EBPalpha. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR3C1 | up-regulates quantity by expression
transcriptional regulation
|
CEBPA |
0.456 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235346 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 11279134 |
The differentiation of 3T3-L1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the CCAAT/enhancer-binding proteins (C/EBPs) and peroxisome proliferator-activated receptor gamma (PPARgamma) by dexamethasone (DEX), 3-isobutyl-1-methylxanthine (MIX), and insulin |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
HDAC1 | down-regulates
transcriptional regulation
|
CEBPA |
0.436 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210013 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16431920 |
These data suggest that c/ebp beta activates a single unified pathway of adipogenesis involving its stimulation of ppargamma expression, which then activates c/ebp alpha expression by dislodging hdac1 from the promoter for degradation in the proteasome |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPA | up-regulates
|
Differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249632 |
|
|
Homo sapiens |
Myeloid Progenitor Cell |
| pmid |
sentence |
| 16319681 |
The transcription factor C/EBPalpha controls differentiation and proliferation in normal granulopoiesis in a stage-specific manner. Loss of C/EBPalpha function in myeloid cells in vitro and in vivo leads to a block to myeloid differentiation similar to that which is observed in malignant cells from patients with acute myeloid leukemia. The finding of C/EBPalpha alterations in subgroups of acute myeloid leukemia patients suggests a direct link between critically decreased C/EBPalpha function and the development of the disorder. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, FLT3 in AML, Onco-fusion proteins in AML, HaematopoiesisTranscriptionalControl, AML_TRIPLETS, FLT3-ITD in AML, Triple mutant AML, NPM1_new |
| + |
Gbeta | down-regulates
phosphorylation
|
CEBPA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270066 |
|
|
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 14701740 |
Ccaat/enhancer-binding protein alpha (c/ebpalpha) is one of the key transcription factors that mediate lineage specification and differentiation of multipotent myeloid progenitors into mature granulocytes.Here we report that inducers of monocyte differentiation inhibit the alternate cell fate choice, that of granulopoiesis, through inhibition of c/ebpalpha. This inhibition is mediated by extracellular signal-regulated kinases 1 and/or 2 (erk1/2), which interact with c/ebpalpha through an fxfp docking site and phosphorylate serine 21. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
dexamethasone | up-regulates
|
CEBPA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250568 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11279134 |
The differentiation of 3t3-l1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the ccaat/enhancer-binding proteins (c/ebps) and peroxisome proliferator-activated receptor gamma (ppargamma) by dexamethasone (dex), 3-isobutyl-1-methylxanthine (mix), and insulin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA1 | down-regulates quantity by repression 
transcriptional regulation
|
CEBPA |
0.402 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254189 |
|
|
Mus musculus |
MEL Cell |
| pmid |
sentence |
| 19825991 |
Gene expression arrays identified components of the PU.1-dependent transcriptome negatively regulated by GATA-1 in MEL cells, including CCAAT/enhancer binding protein alpha (Cebpa) and core-binding factor, beta subunit (Cbfb), which encode two key hematopoietic transcription factors. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
CEBPA | down-regulates activity
|
Mast-Cell_diff |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259967 |
|
|
Mus musculus |
Hematopoietic Stem Cell |
| pmid |
sentence |
| 23990620 |
Notably, enforced overexpression of C/EBP-α in BMCPs results in exclusive differentiation into basophils, whereas conditional deletion of C/EBP-α in these same cells promotes mast cell differentiation,1 suggesting that C/EBP-α is an essential “switch factor” for basophil lineage choice |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
KLF3 | down-regulates
transcriptional regulation
|
CEBPA |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210117 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18391014 |
We find that c/ebpalpha is derepressed in klf3 and ctbp knockout fibroblasts and adipocytes from klf3 knockout mice. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
3-isobutyl-1-methyl-7H-xanthine | up-regulates
|
CEBPA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209992 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11279134 |
The differentiation of 3t3-l1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the ccaat/enhancer-binding proteins (c/ebps) and peroxisome proliferator-activated receptor gamma (ppargamma) by dexamethasone (dex), 3-isobutyl-1-methylxanthine (mix), and insulin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX6 | up-regulates quantity by expression
transcriptional regulation
|
CEBPA |
0.292 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255824 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26893351 |
We found that SOX6 regulates adipogenesis in vertebrate species by activating adipogenic regulators including PPARγ, C/EBPα and MEST |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPA | up-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250562 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 25451943 |
Adipogenesis is controlled by a transcriptional cascade composed of a large number of transcriptional factors, among which CCAAT/enhancer-binding protein (C/EBP) ² plays an essential role. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132946 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17139329 |
C/EBPα induces many adipocyte genes directly, and in vivo studies indicate an important role for this factor in the development of adipose tissue. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
MAP2K1 | up-regulates quantity by expression
transcriptional regulation
|
CEBPA |
0.263 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235325 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 12270934 |
We further show that activation of mek1 significantly enhances the transactivation of the c/ebpalpha minimal promoter during the early phase of the differentiation process. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CEBPA | up-regulates quantity by expression
transcriptional regulation
|
SFTPD |
0.259 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254042 |
|
|
Homo sapiens |
NCI-H441 Cell |
| pmid |
sentence |
| 11912209 |
Cotransfection of C/EBPalpha, C/EBPbeta, or C/EBPdelta cDNA in H441 lung adenocarcinoma cells significantly increased the luciferase activity of a wild-type SP-D promoter construct containing 698 bp of upstream sequence (SS698). Transfection of C/EBP also increased the level of endogenous SP-D mRNA in H441 cells| Thus, interactions among C/EBP elements in the near-distal promoter can modulate the promoter activity of SP-D. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD1 | down-regulates
|
CEBPA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80595 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 10937998 |
Wnt signaling maintains preadipocytes in an undifferentiated state through inhibition of the adipogenic transcription factors ccaat/enhancer binding protein alpha (c/ebpalpha) and peroxisome proliferator- activated receptor gamma (ppargamma) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPA | up-regulates quantity by expression
transcriptional regulation
|
STAR |
0.334 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254043 |
|
|
Homo sapiens |
Endometrial Stromal Cell |
| pmid |
sentence |
| 18583320 |
Electrophoretic mobility shift assay demonstrated that this region of the StAR promoter was bound by C/EBPalpha, C/EBPbeta, and CREB. Forced expression of either C/EBPalpha or C/EBPbeta alone was sufficient to up-regulate StAR promoter activity whereas PGE(2) was needed to induce StAR promoter activity in CREB-overexpressed cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPA | up-regulates activity
|
Granulocyte_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259966 |
|
|
Mus musculus |
Hematopoietic Stem Cell |
| pmid |
sentence |
| 19706798 |
Conditional cebpa deficiency in adult mice blocks the transition from common myeloid progenitors (CMP) to granulocyte monocyte progenitors (GMP) resulting in the accumulation of myeloid blasts |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
CEBPA | up-regulates quantity by expression
transcriptional regulation
|
FTO |
0.347 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261805 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24877091 |
CCAAT/Enhancer-Binding Protein 𝛼 Is a Crucial |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPA | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.49 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253830 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12032779 |
Several different transcription factors have been implicated in the down-regulation of c-myc expression during differentiation, including C/EBPalpha, CTCF, BLIMP-1, and RFX1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, FLT3 in AML, AML_TRIPLETS, FLT3-ITD in AML, Triple mutant AML, NPM1_new |
| + |
NR3C1 | up-regulates quantity by expression
transcriptional regulation
|
CEBPA |
0.456 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256116 |
|
|
Mus musculus |
Preadipocyte Cell Line |
| pmid |
sentence |
| 27777311 |
We show that in addition, DEX-bound GR directly promotes the expression of adipogenic TFs, including C/EBPβ, Klf5, Klf9, and C/EBPα |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
CEBPA | up-regulates quantity by expression
transcriptional regulation
|
SPI1 |
0.529 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261531 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 14592841 |
Activation of C/EBPα induces PU.1 expression, cell cycle arrest, and differentiation in 32D cells expressing FLT3/ITD |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, HaematopoiesisTranscriptionalControl, FLT3-ITD in AML |
| + |
PPARG | up-regulates activity
transcriptional regulation
|
CEBPA |
0.652 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235358 |
|
|
Mus musculus |
MEF Cell, 3T3-L1 Cell, Swiss-3T3 Cell |
| pmid |
sentence |
| 16431920 |
These data suggest that c/ebp beta activates a single unified pathway of adipogenesis involving its stimulation of ppargamma expression, which then activates c/ebp alpha expression by dislodging hdac1 from the promoter for degradation in the proteasome |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
GATA3 | down-regulates
binding
|
CEBPA |
0.361 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250569 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17139329 |
Whereas others, such as GATA2/3 and SMAD3, physically interact with C/EBPα to inhibit its transcriptional activity on the Pparg2 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AML1-ETO | down-regulates activity
binding
|
CEBPA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255700 |
|
|
Homo sapiens |
U-937 Cell |
| pmid |
sentence |
| 11283671 |
AML1–ETO inhibits CEBPA autoregulation in myeloid cells.[…]It was also demonstrated that AML1–ETO and C/EBPα physically interact in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255672 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 11283671 |
Here we show that AML1–ETO blocks C/EBPα –dependent activation of its own promoter and thereby inhibits autoregulation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, Onco-fusion proteins in AML |
| + |
CEBPA | up-regulates activity
binding
|
USF1 |
0.317 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255701 |
|
|
Homo sapiens |
HEP-3B2 Cell |
| pmid |
sentence |
| 7862113 |
Our studies show that the human C/EBPa protein stimulates USF to bind to a USF consensus element within C/EBPa promoter and activates it by two- to threefold.The mechanism by which C/EBPa enhances USF binding and transactivation is currently under study. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NUP98-HOXA9 | down-regulates quantity by repression
transcriptional regulation
|
CEBPA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261501 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17442773 |
Over 102 cytoplasmic mRNAs were significantly altered in K562 myeloid leukemic cells transduced with NUP98‐HOXA9, 92 being increased and only 10 decreased. The transcription factor CCAAT enhancer binding protein‐α (C/EBPα), a tumor suppressor gene and a crucial regulator of granulopoiesis through inhibition of c‐JUN, was downmodulated by NUP98‐HOXA9 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPA | up-regulates
|
Granulocyte_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255674 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11283671 |
We previously reported that the transcription factor C/EBPα is sufficient to induce granulocytic differentiation in multipotential precursor cells, and that Cebpa -knockout mice have a selective block in granulocyte maturation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
CEBPA | up-regulates quantity by expression
transcriptional regulation
|
HSD11B1 |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268971 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19088256 |
Cotransfection with human CCAAT/enhancer binding protein-alpha (C/EBPalpha) and C/EBPbeta-LAP expression vectors activated the HSD11B1 promoter with the strongest effect within the same region. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | down-regulates
|
CEBPA |
0.397 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80589 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 10937998 |
Wnt-10b, is a molecular switch that governs adipogenesis. Wnt signaling maintains preadipocytes in an undifferentiated state through inhibition of the adipogenic transcription factors ccaat/enhancer binding protein alpha (c/ebpalpha) and peroxisome proliferator- activated receptor gamma (ppargamma). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, FLT3 in AML, Onco-fusion proteins in AML, FLT3-ITD in AML |
| + |
NR0B2 | down-regulates activity
binding
|
CEBPA |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254831 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17094771 |
SHP repressed C/EBPalpha (CCAAT/enhancer-binding protein alpha)-driven transcription of PEPCK through direct interaction with C/EBPalpha protein both in vitro and in vivo. The formation of an active transcriptional complex of C/EBPalpha and its binding to DNA was inhibited by SHP, resulting in the inhibition of PEPCK gene transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPA | up-regulates quantity by expression
transcriptional regulation
|
SPI1 |
0.529 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256055 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17671233 |
C/EBPα binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment.Transcriptional induction of PU.1 by C/EBPα may play a role in myeloid lineage specification. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, HaematopoiesisTranscriptionalControl, FLT3-ITD in AML |
| + |
FLT3 | down-regulates quantity by repression
transcriptional regulation
|
CEBPA |
0.631 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261529 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 14592841 |
Thus, induction of C/EBPα and PU.1 expression is inhibited in 32D cells due to the expression of FLT3/ITD |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249635 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16146838 |
Oncogenic mutations of Flt3 also result in the activation of aberrant signaling pathways, including strong activation of STAT5, induction of STAT target genes, and repression of myeloid transcription factors c/EBP-3 and Pu.1. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, FLT3 in AML, AML_TRIPLETS, FLT3-ITD in AML, Triple mutant AML, NPM1_new |
| + |
ERK1/2 | up-regulates
transcriptional regulation
|
CEBPA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235322 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 12270934 |
We demonstrate that exposure of post-confluent 3T3-L1 preadipocytes to insulin, isobutylmethylxanthine (MIX), dexamethasone (DEX), and fetal bovine serum induces a rapid but transient activation of MEK1 as indicated by extensive phosphorylation of ERK1 and ERK2 during the initial 2 h of adipogenesis. We further show that activation of MEK1 significantly enhances the transactivation of the C/EBPalpha minimal promoter during the early phase of the differentiation process. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis, Acute Myeloid Leukemia, FLT3 in AML, AML_TRIPLETS, FLT3-ITD in AML, Triple mutant AML, NPM1_new |
| + |
3-isobutyl-1-methylxanthine | up-regulates
|
CEBPA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-106478 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11279134 |
The differentiation of 3t3-l1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the ccaat/enhancer-binding proteins (c/ebps) and peroxisome proliferator-activated receptor gamma (ppargamma) by dexamethasone (dex), 3-isobutyl-1-methylxanthine (mix), and insulin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD2 | down-regulates
|
CEBPA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80601 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 10937998 |
Wnt signaling maintains preadipocytes in an undifferentiated state through inhibition of the adipogenic transcription factors ccaat/enhancer binding protein alpha (c/ebpalpha) and peroxisome proliferator- activated receptor gamma (ppargamma) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD5 | down-regulates
|
CEBPA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80607 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10937998 |
Wnt signaling maintains preadipocytes in an undifferentiated state through inhibition of the adipogenic transcription factors ccaat/enhancer binding protein alpha (c/ebpalpha) and peroxisome proliferator- activated receptor gamma (ppargamma) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPA | up-regulates quantity by expression
transcriptional regulation
|
HAMP |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253770 |
|
|
Homo sapiens |
HuH-7 Cell |
| pmid |
sentence |
| 18671304 |
HCV-induced ROS stabilized the expression of two negative hepcidin regulators, HIF1alpha and HIF2alpha, and its expression was decreased by a HDAC inhibitor or an anti-oxidant. HCV-induced ROS also caused hypoacetylation of histones and inhibited binding of two positive regulators, C/EBPalpha and STAT3, to the hepcidin promoter, whereas anti-oxidant treatment of cells recovered C/EBPalpha and STAT3 binding to the hepcidin promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPA | up-regulates quantity
transcriptional regulation
|
CEBPA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255673 |
|
|
Homo sapiens |
Myeloid Leukemia Cell |
| pmid |
sentence |
| 11283671 |
Here, we demonstrate that C/EBPα indeed activates its promoter in transient transfection assays in myeloid cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, Acute Myeloid Leukemia, AML1-ETO in AML, FLT3 in AML, Onco-fusion proteins in AML, HaematopoiesisTranscriptionalControl, AML_TRIPLETS, FLT3-ITD in AML, Triple mutant AML, NPM1_new |
| + |
INS | up-regulates
|
CEBPA |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250570 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11279134 |
The differentiation of 3t3-l1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the ccaat/enhancer-binding proteins (c/ebps) and peroxisome proliferator-activated receptor gamma (ppargamma) by dexamethasone (dex), 3-isobutyl-1-methylxanthine (mix), and insulin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis |
| + |
CEBPA | up-regulates quantity by expression
transcriptional regulation
|
PER2 |
0.425 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256369 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22260161 |
We have previously shown that PER2 is a downstream CCAAT-enhancer-binding protein (C/EBP)-target gene, and its disruption might be involved in the initiation and progression of acute myelogenous leukemia (AML) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF3 | down-regulates quantity by repression
transcriptional regulation
|
CEBPA |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-161370 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18391014 |
We find that c/ebpalpha is derepressed in klf3 and ctbp knockout fibroblasts and adipocytes from klf3 knockout mice. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPA | down-regulates
transcriptional regulation
|
SOX4 |
0.382 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255675 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24183681 |
In summary, our data demonstrate that C/EBPα negatively regulates Sox4 transcription via direct DNA-binding. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, FLT3 in AML, AML_TRIPLETS, Triple mutant AML |
| + |
CEBPA | up-regulates quantity by expression
transcriptional regulation
|
F9 |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254040 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 8075306 |
Transactivation by the CCAAT/enhancer binding protein alpha of the wild-type and mutated factor IX promoter (-192 to +38) resulted in an approximately four-fold and approximately two-fold, respectively, increase of CAT activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD3 | down-regulates activity
binding
|
CEBPA |
0.376 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241924 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12524424 |
Thus, repression of the activity of C/EBPs by Smad3/4 at C/EBP binding sites inhibited transcription from the PPAR2 and leptin promoters |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
HDAC1 | down-regulates quantity by repression
transcriptional regulation
|
CEBPA |
0.436 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143955 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16431920 |
These data suggest that c/ebp beta activates a single unified pathway of adipogenesis involving its stimulation of ppargamma expression, which then activates c/ebp alpha expression by dislodging hdac1 from the promoter for degradation in the proteasome |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USF1 | up-regulates quantity by expression
transcriptional regulation
|
CEBPA |
0.317 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255702 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7862113 |
Our studies show that the human C/EBPa protein stimulates USF to bind to a USF consensus element within C/EBPa promoter and activates it by two- to threefold.The mechanism by which C/EBPa enhances USF binding and transactivation is currently under study. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD3/SMAD4 | down-regulates activity
binding
|
CEBPA |
0.367 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250571 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12524424 |
C/EBPbeta and C/EBPdelta were found to physically interact with Smad3 and Smad4, and Smad3 cooperated with Smad4 and TGF-beta signaling to repress the transcriptional activity of C/EBPs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPA | up-regulates quantity by expression
transcriptional regulation
|
GFI1 |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256068 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20924107 |
We show here that C/EBPα interacts with a functional C/EBP binding site in the Gfi-1 5'-flanking region and enhances the promoter activity of Gfi-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
PML-RARalpha | down-regulates quantity by repression
transcriptional regulation
|
CEBPA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255726 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19797526 |
We therefore conclude that PML-RARα–mediated repression of C/EBPα is driven through a DNA methylation pathway. In accordance with this finding, a recent study in human APL samples described increased C/EBPα promoter methylation, consistent with the ability of PML-RARα to recruit corepressor complexes. Moreover, the PML-RARα effect on C/EBPα repression does not seem to be mediated via direct binding. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML, Onco-fusion proteins in AML |
| + |
CEBPA | up-regulates activity
|
Monocyte_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259965 |
|
|
Mus musculus |
Hematopoietic Stem Cell |
| pmid |
sentence |
| 19706798 |
Conditional cebpa deficiency in adult mice blocks the transition from common myeloid progenitors (CMP) to granulocyte monocyte progenitors (GMP) resulting in the accumulation of myeloid blasts |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
CREBL2 | up-regulates quantity by expression
transcriptional regulation
|
CEBPA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261574 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 21728997 |
Accordingly, the results of QPCR and immunoblot analysis showed that during adipogenesis, both the mRNA (Figures 4D and 4E) and protein (Figure 4F) levels of PPARγ , as well as C/EBPα, in 3T3-L1 preadipocytes transfected with either siCREBL2-1 or siCREBL2-2 were significantly decreased compared with the control (P < 0.05), suggesting that knockdown of CREBL2 protein suppress 3T3-L1 preadipocyte differentiation via inhibition of PPARγ and C/EBPα expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CEBPA | up-regulates activity
|
Basophil_diff |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259968 |
|
|
Mus musculus |
Hematopoietic Stem Cell |
| pmid |
sentence |
| 23990620 |
Notably, enforced overexpression of C/EBP-α in BMCPs results in exclusive differentiation into basophils, whereas conditional deletion of C/EBP-α in these same cells promotes mast cell differentiation,1 suggesting that C/EBP-α is an essential “switch factor” for basophil lineage choice |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MEK1/2 | up-regulates quantity by expression
transcriptional regulation
|
CEBPA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244773 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 12270934 |
We further show that activation of mek1 significantly enhances the transactivation of the c/ebpalpha minimal promoter during the early phase of the differentiation process. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis, Acute Myeloid Leukemia, FLT3 in AML, AML_TRIPLETS, NPM1_new |
| + |
DDIT3 | down-regulates quantity
transcriptional regulation
|
CEBPA |
0.52 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255913 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 7588595 |
We find that expression of CHOP, a nuclear protein that dimerizes avidly with C/EBP isoforms alpha and beta and directs the resulting heterodimer away from classic C/EBP-binding sites, markedly inhibits this differentiation process. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CEBPA | up-regulates quantity by expression
transcriptional regulation
|
ELANE |
0.308 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253769 |
|
|
Homo sapiens |
Culture Condition:CD34+ Cell |
| pmid |
sentence |
| 19620402 |
The ELA2 gene promoter is positively regulated by the direct binding of LEF-1 or C/EBPalpha, documenting the role of LEF1 in the diminished ELA2 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPA | up-regulates quantity by expression
transcriptional regulation
|
S100A9 |
0.227 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254041 |
|
|
Homo sapiens |
THP-1 Cell |
| pmid |
sentence |
| 9706399 |
Among several known transcription factor binding motifs, nuclear protein(s) of VD3-treated HL-60 cells and THP-1 cells bound to the CCAAT/enhancer binding protein (C/EBP)-binding motif that was located in the upstream region of the MRP14 gene (-81), as evidenced by the competitive gel mobility-shift assay.|Thus, it was concluded that C/EBP alpha and -beta were able to bind to the C/EBP motif, and that C/EBP alpha bound to the motif in THP-1 cells and C/EBP beta bound to that in the VD3-treated HL-60 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CEBPA
- 
- 