Summary

Name PEBP1
Full Name Phosphatidylethanolamine-binding protein 1
Synonyms PEBP-1, HCNPpp, Neuropolypeptide h3, Prostatic-binding protein, Raf kinase inhibitor protein, RKIP | PBP, PEBP
Primary ID P30086
Links - -
Type protein
Relations 3
Function Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation PEBP1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PEBP1 0.14
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates img/direct_inhibition.png binding RAF1 0.52
Publications: 1 Organism: Homo Sapiens