3.0
Summary
| Name |  PEBP1View Modifications |
| Full Name | Phosphatidylethanolamine-binding protein 1 |
| Synonyms | PEBP-1, HCNPpp, Neuropolypeptide h3, Prostatic-binding protein, Raf kinase inhibitor protein, RKIP | PBP, PEBP |
| Primary ID | P30086 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCG | up-regulates activity 
phosphorylation
|
PEBP1 | 0.389 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | PRKCD | up-regulates
phosphorylation
|
PEBP1 | 0.305 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK5 | down-regulates quantity by destabilization 
phosphorylation
|
PEBP1 | 0.344 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PEBP1 | down-regulates
binding
|
RAF1 | 0.753 |
| Publications: | 1 | Organism: | Homo Sapiens | |