3.0
Summary
| Name |  FCGR2BView Modifications |
| Full Name | Low affinity immunoglobulin gamma Fc region receptor II-b |
| Synonyms | IgG Fc receptor II-b, CDw32, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b | CD32, FCG2, IGFR2 |
| Primary ID | P31994 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | LYN | up-regulates activity 
phosphorylation
|
FCGR2B | 0.44 |
| Publications: | 1 | Organism: | In Vitro | |
| + | MARCHF9 | down-regulates quantity by destabilization 
ubiquitination
|
FCGR2B | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Immune complexes | up-regulates activity 
|
FCGR2B | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FCGR2B | down-regulates activity 
|
TLR4 | 0.391 |
| Publications: | 1 | Organism: | Homo Sapiens | |