| + |
TLR4 | up-regulates activity 
phosphorylation
|
JNK |
0.501 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261929 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28137827 |
Binding of S100A9 to TLR4 stimulates the phosphorylation of JNK, ERK1/2, and p38 MAPK, which leads to the activation of c-Jun, CREB, and NF-κB. Activation of neutrophils by S100A9 also proceeds via p38 MAPK, JNK, and ERK1/2 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
S100A8 | down-regulates activity 
binding
|
TLR4 |
0.515 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261921 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28137827 |
Interestingly, in the present study, we report that extracellular S100A9 induces terminal differentiation of myeloid leukemia cells in human and murine AMLs after TLR4 activation, which is highly expressed by primary myelomonocytic and monocytic leukemia cells. In contrast, anti-S100A8 induced the differentiation of AML cells, suggesting that the differentiation-promoting effect of S100A9 is inhibited by S100A8. ) S100A8 could bind to TLR4 and activate different signaling pathways, leading to the inhibition of cellular differentiation induced by S100A9. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLR4 | up-regulates 
|
Immune_response |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166485 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20596954 |
Regulation of toll-like receptor signaling in the innate immunity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLR4 | up-regulates activity
|
NfKb-p65/p50 |
0.564 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249517 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 7635431 |
The activation of NF-kB is triggered by different stimuli, eg., lipopolysaccharides (LPSs), muramyl peptides, viruses,e inflammatory cytokines tumor necrosis factor-alpha(TNF-a) and interleukin (IL)-1b, irradiation, and reactive xygen intermediates (H2O2). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling, Macrophage polarization |
| + |
TLR4 | up-regulates activity
binding
|
TLR4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252066 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22664090 |
To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TLR pathways, is usually considered a part of the TIR domain-containing adaptor protein group |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | FLT3-ITD signaling, Macrophage polarization |
| + |
TLR4 | up-regulates activity
phosphorylation
|
ERK1/2 |
0.44 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261930 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28137827 |
Binding of S100A9 to TLR4 stimulates the phosphorylation of JNK, ERK1/2, and p38 MAPK, which leads to the activation of c-Jun, CREB, and NF-κB. Activation of neutrophils by S100A9 also proceeds via p38 MAPK, JNK, and ERK1/2 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
TLR4 | up-regulates activity
binding
|
TICAM1 |
0.844 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252067 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22664090 |
To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TLR pathways, is usually considered a part of the TIR domain-containing adaptor protein group |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Macrophage polarization |
| + |
TLR4 | up-regulates activity
|
JUN |
0.456 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249518 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 19592489 |
The transcription factor AP-1 consists of a variety of dimers composed of members of the Jun, Fos, and ATF families of proteins. The Jun proteins can both homo- and heterodimerize with Fos members to form transcriptionally active complexes. The stimulation of macrophage TLR4 receptor rapidly activates not only the NF-kappaB pathway but also MAPK pathways, including JNK, ERK, and p38. Many of the downstream targets of MAPK pathways are transcription factors that include c-Jun. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLR4 | up-regulates
binding
|
TICAM2 |
0.723 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160424 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18221795 |
Mappit analysis of early toll-like receptor signalling events. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization |
| + |
RNF216 | down-regulates quantity by destabilization
ubiquitination
|
TLR4 |
0.397 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271504 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15107846 |
Here we describe how a RING finger protein, Triad3A, acts as an E3 ubiquitin-protein ligase and enhances ubiquitination and proteolytic degradation of some TLRs. Triad3A overexpression promoted substantial degradation of TLR4 and TLR9 with a concomitant decrease in signaling, but did not affect TLR2 expression or signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
lipopolysaccharide | up-regulates activity
chemical activation
|
TLR4 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252075 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9851930 |
The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TLR4 | up-regulates activity
binding
|
TIRAP |
0.772 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252064 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11544529 |
Here we describe a protein, Mal (MyD88-adapter-like), which joins MyD88 as a cytoplasmic TlR-domain-containing protein in the human genome. Mal activates NF-_B, Jun amino-terminal kinase and extracellular signal-regulated kinase-1 and -2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLR4 | up-regulates
binding
|
TLR4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-203484 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24352680 |
Upon activation, tlrs hetero- or homodimerize inducing the recruitment of adaptor proteins via the cytoplasmic tir domain |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling, Macrophage polarization |
| + |
TLR4 | up-regulates activity
binding
|
MYD88 |
0.761 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252065 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22664090 |
To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TLR pathways, is usually considered a part of the TIR domain-containing adaptor protein group |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
HMGB1 | up-regulates activity
binding
|
TLR4 |
0.796 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252057 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20547845 |
Here we show that Toll-like receptor 4 (TLR4), a pivotal receptor for activation of innate immunity and cytokine release, is required for HMGB1-dependent activation of macrophage TNF release. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
S100A9 | up-regulates activity
binding
|
TLR4 |
0.527 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261918 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28137827 |
RAGE and TLR4 are well-characterized S100A8 and S100A9 receptors and expressed in AML cells. S100A9 binds to TLR4 and induces signaling pathways,promoting leukemic cell differentiation and proliferation arrest. Binding of S100A9 to TLR4 stimulates the phosphorylation of JNK, ERK1/2, and p38 MAPK, which leads to the activation of c-Jun, CREB, and NF-kB. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
TLR4 | up-regulates activity
phosphorylation
|
p38 |
0.427 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261928 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28137827 |
Binding of S100A9 to TLR4 stimulates the phosphorylation of JNK, ERK1/2, and p38 MAPK, which leads to the activation of c-Jun, CREB, and NF-κB. Activation of neutrophils by S100A9 also proceeds via p38 MAPK, JNK, and ERK1/2 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLR4 | up-regulates activity
|
MAP3K8 |
0.399 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256083 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16484370 |
Our findings indicate that the Tpl2/MEK/ERK signaling module is a master regulator of ERK-dependent gene expression downstream of TLRs in different hemopoietic cells |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PAMPs | up-regulates activity
|
TLR4 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249516 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 19946286 |
The lipopolysaccharide (LPS) of Gram negative bacteria is a wellknown inducer of the innate immune response1. Toll-like receptor (TLR) 4 and myeloid differentiation factor 2 (MD-2) form a heterodimer that recognizes a common pattern in structurally diverse LPS molecules. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization |
| + |
TLR4 | up-regulates
|
Interferon_Production |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166488 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20596954 |
Regulation of toll-like receptor signaling in the innate immunity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLR4 | up-regulates activity
phosphorylation
|
MAPK14 |
0.427 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263652 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28137827 |
Binding of S100A9 to TLR4 stimulates the phosphorylation of JNK, ERK1/2, and p38 MAPK, which leads to the activation of c-Jun, CREB, and NF-κB. Activation of neutrophils by S100A9 also proceeds via p38 MAPK, JNK, and ERK1/2 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
TLR4 | up-regulates
binding
|
TIRAP |
0.772 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-110337 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11544529 |
Mal (myd88-adapter-like) is required for toll-like receptor-4 signal transduction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FCGR2B | down-regulates activity 
|
TLR4 |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249525 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24445665 |
Triggering of FcgammaRIIB also subverted the normal activation of DCs by the TLR4 agonist lipopolysaccharide. In addition, triggering of FcgammaRIIB by immune complexes might affect the differentiation of moDCs. When moDCs develop from monocytes invitro in the presence of immune complexes, their differentiation is hampered and they no longer produce IL-12 in response to TLR4 agonists. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLR4 | up-regulates
|
Differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261923 |
|
|
Homo sapiens |
Acute Myeloid Leukemia Cell |
| pmid |
sentence |
| 28137827 |
S100A9 induces differentiation of acute myeloid leukemia cells through TLR4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TLR4
- 
- 