+ |
RAB5A | up-regulates activity
binding
|
INPP5B |
0.46 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-277770 |
|
|
Homo sapiens |
|
pmid |
sentence |
33722976 |
We report that Rab5 acts at the plasma membrane, downstream of ruffling, to promote macropinosome sealing and scission. Rab5 is recruited to plasmalemmal circular ruffles before macropinosome closure. Rab5 effectors Inpp5b, OCRL and APPL1 localize to macropinocytic cups and vesicles, and are required for macropinosome sealing. The mammalian 5-phosphatases Inpp5b and OCRL, which can degrade PtdIns(4,5)P2, are both Rab5-associating effectors implicated in endocytosis and macropinocytosis |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
INPP5B | down-regulates quantity
chemical modification
|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-277772 |
|
|
Homo sapiens |
|
pmid |
sentence |
33722976 |
We report that Rab5 acts at the plasma membrane, downstream of ruffling, to promote macropinosome sealing and scission. Rab5 is recruited to plasmalemmal circular ruffles before macropinosome closure. Rab5 effectors Inpp5b, OCRL and APPL1 localize to macropinocytic cups and vesicles, and are required for macropinosome sealing. The mammalian 5-phosphatases Inpp5b and OCRL, which can degrade PtdIns(4,5)P2, are both Rab5-associating effectors implicated in endocytosis and macropinocytosis |
|
Publications: |
1 |
Organism: |
Homo Sapiens |