+ |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | form complex
binding
|
AP-2/clathrin vescicle |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260664 |
|
|
Homo sapiens |
|
pmid |
sentence |
24789820 |
AP2 adaptor complexes, associated at the membrane with PtdIns(4,5)P2 (PIP2), recruit clathin triskelions to initiate lattice assembly. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | up-regulates quantity
precursor of
|
1,2-diacyl-sn-glycerol |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268451 |
|
|
Homo sapiens |
|
pmid |
sentence |
23000145 |
Upon stimulation with various immune receptors, PLCγ2 cleaves the membrane-bound phospholipid phosphatidyl inositol-4, 5-biphosphate (PIP2) into the second messenger molecules inositol-1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | B-cell activation |
+ |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | form complex
binding
|
AP-3/clathrin vescicle |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260669 |
|
|
Homo sapiens |
|
pmid |
sentence |
23103167 |
Clathrin-coated pits and vesicles are diffraction-limited objects with typical diameters ranging between 75 and 130 nm. The smaller ∼75 nm coats contain at least 36 copies of clathrin, a heterohexameric protein of three heavy chains and three light chains, and about half that number of copies of the heterotetrameric AP adaptor complex | Intracellular clathrin-coated vesicles contain AP1 or AP3 adaptors |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PLCG2 | down-regulates quantity
chemical modification
|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268452 |
|
|
Homo sapiens |
|
pmid |
sentence |
23000145 |
Upon stimulation with various immune receptors, PLCγ2 cleaves the membrane-bound phospholipid phosphatidyl inositol-4, 5-biphosphate (PIP2) into the second messenger molecules inositol-1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | B-cell activation |
+ |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | up-regulates quantity
precursor of
|
1D-myo-inositol 1,4,5-trisphosphate |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268450 |
|
|
Homo sapiens |
|
pmid |
sentence |
23000145 |
Upon stimulation with various immune receptors, PLCγ2 cleaves the membrane-bound phospholipid phosphatidyl inositol-4, 5-biphosphate (PIP2) into the second messenger molecules inositol-1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | B-cell activation |