Macropinocytosis

Pathway ID: SIGNOR-M

Description: Macropinocytosis is a non-selective form of endocytosis where cells internalize large volumes of extracellular fluid, nutrients, and other macromolecules, primarily through membrane ruffling. This pathway plays an important role in various cellular processes, including nutrient uptake, immune response, cell migration, and cancer cell metabolism. Macropinocytosis is regulated by a range of signaling pathways that influence the actin cytoskeleton and membrane dynamics to drive macropinosome formation.

Curated by: Marta Iannuccelli

37 Seed Entities

Organism:
Name Primary ID
KRAS P01116
glucose CHEBI:17234
WAVE complex SIGNOR-C271
RAB21 Q9UL25
Macropinosomes formation SIGNOR-PH227
cholesterol CHEBI:16113
PAK1 Q13153
hydrogencarbonate CHEBI:17544
Late macropinosomes SIGNOR-PH229
RAC1 P63000
Av/b3 integrin SIGNOR-C177
3',5'-cyclic AMP CHEBI:17489
GF SIGNOR-PF39
HRAS P01112
AMPK SIGNOR-C15
LGALS3 P17931
ALS2 Q96Q42
SOS1 Q07889
Vesicle_transport SIGNOR-PH172
GRB2 P62993
PKA SIGNOR-PF17
CDC42 P60953
V-ATPase SIGNOR-C560
OCRL Q01968
ARF6 P62330
INPP5B P32019
RAB5A P20339
RTKs SIGNOR-PF38
Early macropinosomes SIGNOR-PH228
RHOA P61586
ARP2/3 SIGNOR-C146
ADCY10 Q96PN6
F-actin_assembly SIGNOR-PH18
PI3K SIGNOR-C156
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate CHEBI:18348
RAB7A P51149
PIP3 CHEBI:16618