Macropinocytosis

Pathway ID: SIGNOR-M

Description: Macropinocytosis is a non-selective form of endocytosis where cells internalize large volumes of extracellular fluid, nutrients, and other macromolecules, primarily through membrane ruffling. This pathway plays an important role in various cellular processes, including nutrient uptake, immune response, cell migration, and cancer cell metabolism. Macropinocytosis is regulated by a range of signaling pathways that influence the actin cytoskeleton and membrane dynamics to drive macropinosome formation.

Curated by: Marta Iannuccelli

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41 Seed Entities

Organism:
Name Primary ID
mTORC1 SIGNOR-C3
WAVE complex SIGNOR-C271
RAB21 Q9UL25
Macropinosomes formation SIGNOR-PH227
cholesterol CHEBI:16113
Late macropinosomes SIGNOR-PH229
RAC1 P63000
Lysosome fusion SIGNOR-PH231
Av/b3 integrin SIGNOR-C177
LGALS3 P17931
ALS2 Q96Q42
GRB2 P62993
PKA SIGNOR-PF17
V-ATPase SIGNOR-C560
OCRL Q01968
INPP5B P32019
Early macropinosomes SIGNOR-PH228
RHOA P61586
ARP2/3 SIGNOR-C146
ADCY10 Q96PN6
F-actin_assembly SIGNOR-PH18
PI3K SIGNOR-C156
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate CHEBI:18348
RAB7A P51149
KRAS P01116
glucose CHEBI:17234
PAK1 Q13153
hydrogencarbonate CHEBI:17544
GIT1 Q9Y2X7
3',5'-cyclic AMP CHEBI:17489
GF SIGNOR-PF39
HRAS P01112
AMPK SIGNOR-C15
Macropinosomes recycle SIGNOR-PH230
SOS1 Q07889
CDC42 P60953
ARF6 P62330
RAB5A P20339
RTKs SIGNOR-PF38
MCOLN1 Q9GZU1
PIP3 CHEBI:16618