Relation Results

Summary

Name KIF5B
Full Name Kinesin-1 heavy chain
Synonyms Conventional kinesin heavy chain, Ubiquitous kinesin heavy chain, UKHC | KNS, KNS1
Primary ID P33176
Links - -
Type protein
Relations 7
Function Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions ...
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Type: Score: Layout: SPV 
0.20.70.70.20.5980.2570.571KIF5BJAKMIP1Organelle_transportPlus-end directed sliding movementDISC1KTN1GABBR1SYBU

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Relations
Regulator
Mechanism
target
score ℹ
+ KIF5Bup-regulates activity img/direct-activation.png relocalization JAKMIP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260989 Mus musculus
pmid sentence
Marlin-1 is associated with kinesin-I and suggest that the movement of Marlin-1 is mediated by plus end microtubuledependent molecular motors
Publications: 1 Organism: Mus Musculus
+ KIF5Bup-regulates img/indirect-activation.png Organelle_transport 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264068 Homo sapiens Neuron
pmid sentence
The kinesin superfamily of proteins plays a major role in this complex organelle transport. Kinesin is primarily associated with anterogradely transported membranous organelles in nerve axons. KIF5B and HsuKHC are expressed ubiquitously in many tissues, whereas KIF5A, KIF5C, and HsnKHC are specific to nerve tissue.
Publications: 1 Organism: Homo Sapiens
+ KIF5Bup-regulates img/indirect-activation.png Plus-end directed sliding movement 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-272520 Homo sapiens
pmid sentence
In general, N-kinesins and C-kinesins drive microtubule plus end- and minus end-directed motilities, respectively, and M-kinesins depolymerize microtubules1,9 (Box 1).|Forty-five genes that encode kinesin superfamily proteins (also known as KIFs) have been discovered in the mouse and human genomes.|KIFs are molecular motors that directionally transport various cargos, including membranous organelles, protein complexes and mRNAs, along the microtubule system.
Publications: 1 Organism: Homo Sapiens
+ DISC1up-regulates activity img/direct-activation.png binding KIF5B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252161 Homo sapiens Neuron
pmid sentence
We identified Kinesin-1, a microtubule-dependent and plus-end directed motor, as a DISC1-interacting molecule. Our results show that DISC1 links Kinesin-1 to the NUDEL/LIS1/14-3-3ε complex, serves as the cargo receptor, and regulates the transport of the complex to axons, leading to axon elongation. DISC1 directly interacted with kinesin heavy chain of Kinesin-1. Kinesin-1 interacted with the NUDEL/LIS1/14-3-3ε complex through DISC1
Publications: 1 Organism: Homo Sapiens
+ KTN1up-regulates img/direct-activation.png binding KIF5B 0.598
Identifier Residue Sequence Organism Cell Line
SIGNOR-128092 Homo sapiens
pmid sentence
This study demonstrated the effect of kinectin-kinesin interaction on lysosome dynamics and observed that the kinesin-binding domain of kinectin can significantly enhance the mt-stimulated atpase activity of kinesin.
Publications: 1 Organism: Homo Sapiens
+ KIF5Bup-regulates activity img/direct-activation.png relocalization GABBR1 0.257
Identifier Residue Sequence Organism Cell Line
SIGNOR-260990 Mus musculus
pmid sentence
GABABR1 co-immunoprecipitated with Marlin-1 and kinesin-I, providing evidence for the existence of a complex between these proteins. Kinesin-I modulates GABAB receptor transport.
Publications: 1 Organism: Mus Musculus
+ KIF5Bup-regulates activity img/direct-activation.png relocalization SYBU 0.571
Identifier Residue Sequence Organism Cell Line
SIGNOR-264811 Homo sapiens Neuron
pmid sentence
Conventional kinesin I heavy chain binds to syntabulin and associates with syntabulin-linked syntaxin vesicles in vivo. These findings suggest that syntabulin functions as a linker molecule that attaches syntaxin-cargo vesicles to kinesin I, enabling the transport of syntaxin-1 to neuronal processes.
Publications: 1 Organism: Homo Sapiens
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