| + |
CyclinA2/CDK2 | down-regulates 
phosphorylation
|
MCM4 |
0.687 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217344 |
Ser32 |
RSEDARSsPSQRRRG |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12714602 |
We reported that the dna helicase activity of the human and mouse mcm4-6-7 complex, a sub-complex of the mcm2-7 heterohexamer, is inhibited by the phosphorylation by cdk2-cyclin a we identified six sites, including ser-32, ser-53, and thr-109, in the amino-terminal region of mouse mcm4 that are required for the phosphorylation with cdk2-cyclin a. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217348 |
Ser54 |
ELQPMPTsPGVDLQS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12714602 |
We reported that the dna helicase activity of the human and mouse mcm4-6-7 complex, a sub-complex of the mcm2-7 heterohexamer, is inhibited by the phosphorylation by cdk2-cyclin a we identified six sites, including ser-32, ser-53, and thr-109, in the amino-terminal region of mouse mcm4 that are required for the phosphorylation with cdk2-cyclin a. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217352 |
Thr110 |
PRSGVRGtPVRQRPD |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12714602 |
We reported that the dna helicase activity of the human and mouse mcm4-6-7 complex, a sub-complex of the mcm2-7 heterohexamer, is inhibited by the phosphorylation by cdk2-cyclin a we identified six sites, including ser-32, ser-53, and thr-109, in the amino-terminal region of mouse mcm4 that are required for the phosphorylation with cdk2-cyclin a. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CDK2 | down-regulates activity
phosphorylation
|
MCM4 |
0.758 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100881 |
Ser32 |
RSEDARSsPSQRRRG |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12714602 |
We reported that the dna helicase activity of the human and mouse mcm4-6-7 complex, a sub-complex of the mcm2-7 heterohexamer, is inhibited by the phosphorylation by cdk2-cyclin a we identified six sites, including ser-32, ser-53, and thr-109, in the amino-terminal region of mouse mcm4 that are required for the phosphorylation with cdk2-cyclin a. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100885 |
Ser54 |
ELQPMPTsPGVDLQS |
Homo sapiens |
|
| pmid |
sentence |
| 12714602 |
We reported that the dna helicase activity of the human and mouse mcm4-6-7 complex, a sub-complex of the mcm2-7 heterohexamer, is inhibited by the phosphorylation by cdk2-cyclin a we identified six sites, including ser-32, ser-53, and thr-109, in the amino-terminal region of mouse mcm4 that are required for the phosphorylation with cdk2-cyclin a. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100889 |
Thr110 |
PRSGVRGtPVRQRPD |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12714602 |
We reported that the dna helicase activity of the human and mouse mcm4-6-7 complex, a sub-complex of the mcm2-7 heterohexamer, is inhibited by the phosphorylation by cdk2-cyclin a we identified six sites, including ser-32, ser-53, and thr-109, in the amino-terminal region of mouse mcm4 that are required for the phosphorylation with cdk2-cyclin a. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100893 |
Thr19 |
GSRRGRAtPAQTPRS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12714602 |
We report here that human mcm4, a subunit of the putative dna replicative helicase, is extensively phosphorylated in hela cells when they are incubated in the presence of inhibitors of dna synthesis or are exposed to uv irradiation. The data presented here indicate that the consecutive actions of atr-chk1 and cdk2 kinases are involved in this phosphorylation in the presence of hydroxyurea. Phosphorylation of t19 correlates with lowered level of dna helicase activity of the purified mcm4,6,7 complex. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
CDK1 | down-regulates activity
phosphorylation
|
MCM4 |
0.609 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100877 |
Thr19 |
GSRRGRAtPAQTPRS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12714602 |
We report here that human mcm4, a subunit of the putative dna replicative helicase, is extensively phosphorylated in hela cells when they are incubated in the presence of inhibitors of dna synthesis or are exposed to uv irradiation. The data presented here indicate that the consecutive actions of atr-chk1 and cdk2 kinases are involved in this phosphorylation in the presence of hydroxyurea. Phosphorylation of t19 correlates with lowered level of dna helicase activity of the purified mcm4,6,7 complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATR | up-regulates 
phosphorylation
|
MCM4 |
0.714 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169412 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21070963 |
Together these data strongly support the conclusion that mec1 directly targets the s/tq sites in mcm4 and mcm6, although it is formally possible that mec1 and mrc1 activate a different s/tq-directed kinase to target mcm4 and mcm6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MCM4 | form complex 
binding
|
MCM |
0.765 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261674 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19946136 |
The Mcm2-7 complex serves as the eukaryotic replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDC7 | up-regulates
phosphorylation
|
MCM4 |
0.957 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169453 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21070963 |
Activation of the eukaryotic replicative dna helicase, the mcm2-7 complex, requires phosphorylation by cdc7/dbf4 (dbf4-dependent kinase or ddk), which, in turn, depends on prior phosphorylation of mcm2-7 by an unknown kinase (or kinases).we propose that the resulting mec1 modification of mcm4 and mcm6 further activates ddk phosphorylation of mcm2-7 ( fig. 7aii ). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MCM4
- 
- 