| + |
CEBPB | up-regulates quantity by expression 
transcriptional regulation
|
ADM |
0.246 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254047 |
|
|
|
|
| pmid |
sentence |
| 9480831 |
These findings suggest that NF-IL6 and AP-2 sites in the promoter region are the functional elements in the transcriptional regulation of human AM gene in vascular endothelial cells. |
|
| Publications: |
1 |
| + |
ADM | up-regulates activity
binding
|
Adrenomedullin receptor AM2 complex |
0.71 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281151 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12196109 |
Adrenomedullin is a vascular tissue peptide and a member of the calcitonin family of peptides, which includes calcitonin, calcitonin-gene-related peptide (CGRP) and amylin. Its many biological actions are mediated via CGRP type 1 (CGRP(1)) receptors and by specific adrenomedullin receptors. Although the pharmacology of these receptors is distinct, they are both represented in molecular terms by the type II family G-protein-coupled receptor, calcitonin-receptor-like receptor (CRLR). The specificity here is defined by co-expression of receptor-activity-modifying proteins (RAMPs). CGRP(1) receptors are represented by CRLR and RAMP1, and specific adrenomedullin receptors by CRLR and RAMP2 or 3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADM | up-regulates activity
binding
|
Adrenomedullin receptor AM1 complex |
0.714 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281152 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12196109 |
Adrenomedullin is a vascular tissue peptide and a member of the calcitonin family of peptides, which includes calcitonin, calcitonin-gene-related peptide (CGRP) and amylin. Its many biological actions are mediated via CGRP type 1 (CGRP(1)) receptors and by specific adrenomedullin receptors. Although the pharmacology of these receptors is distinct, they are both represented in molecular terms by the type II family G-protein-coupled receptor, calcitonin-receptor-like receptor (CRLR). The specificity here is defined by co-expression of receptor-activity-modifying proteins (RAMPs). CGRP(1) receptors are represented by CRLR and RAMP1, and specific adrenomedullin receptors by CRLR and RAMP2 or 3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DMTF1 | up-regulates quantity by expression 
transcriptional regulation
|
ADM |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261581 |
|
|
Mus musculus |
C-10 Cell |
| pmid |
sentence |
| 19816943 |
Notably, amphiregulin (Areg), thrombospondin-1 (Tsp-1), JunB, Egr1, adrenomedullin (Adm), Bcl-3 and methyl-CpG binding domain protein 1 (Mbd1) were downregulated in the lungs from Dmp1-null mice while Gas1 and Ect2 genes were upregulated. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TFAP2A | up-regulates quantity by expression
transcriptional regulation
|
ADM |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254048 |
|
|
|
|
| pmid |
sentence |
| 9480831 |
These findings suggest that NF-IL6 and AP-2 sites in the promoter region are the functional elements in the transcriptional regulation of human AM gene in vascular endothelial cells. |
|
| Publications: |
1 |
4.0
ADM
- 
- 