3.0
Summary
| Name |  TFAP2AView Modifications |
| Full Name | Transcription factor AP-2-alpha |
| Synonyms | AP2-alpha, AP-2 transcription factor, Activating enhancer-binding protein 2-alpha, Activator protein 2, AP-2 | AP2TF, TFAP2 |
| Primary ID | P05549 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Function | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKACA | up-regulates 
phosphorylation
|
TFAP2A | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CSNK2A1 | up-regulates
phosphorylation
|
TFAP2A | 0.311 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TFAP2A | up-regulates quantity by expression 
transcriptional regulation
|
LNPEP | 0.284 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TFAP2A | up-regulates quantity by expression
transcriptional regulation
|
ADM | 0.271 |
| Publications: | 1 | |||
| + | TFAP2A | up-regulates quantity by expression
transcriptional regulation
|
CRYAB | 0.263 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TFAP2A | up-regulates quantity by expression
transcriptional regulation
|
CRABP2 | 0.351 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TFAP2A | up-regulates quantity by expression
transcriptional regulation
|
ECM1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TFAP2A | up-regulates quantity by expression
transcriptional regulation
|
SULT1E1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TFAP2A | up-regulates quantity by expression
transcriptional regulation
|
DCC | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |