Relation Results

Summary

Name GCK
Full Name Hexokinase-4
Synonyms Hexokinase type IV, HK IV, Hexokinase-4, HK4, Hexokinase-D |
Primary ID P35557
Links - -
Type protein
Relations 4
Function Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosp ...
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Type: Score: Layout: SPV 
0.2910.80.6020.8USF1GCKalpha-D-glucose 6-phosphate(2-)PDX1α-D-glucose

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Relations
Regulator
Mechanism
target
score ℹ
+ USF1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GCK 0.291
Identifier Residue Sequence Organism Cell Line
SIGNOR-255597 Homo sapiens
pmid sentence
Cotransfection of an expression plasmid encoding USF1 into HepG2 hepatoma cells resulted in the activation of the glucokinase promoter, dependent on the integrity of the P2 element
Publications: 1 Organism: Homo Sapiens
+ GCKup-regulates quantity img/direct-activation.png chemical modification alpha-D-glucose 6-phosphate(2-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266448 Homo sapiens
pmid sentence
Hexokinase catalyzes the phosphorylation of glucose to G6P, using ATP as a phosphoryl donor.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ PDX1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GCK 0.602
Identifier Residue Sequence Organism Cell Line
SIGNOR-254911 Homo sapiens
pmid sentence
The glycolytic enzyme glucokinase plays a primary role in the glucose-responsive secretion of insulin, and defects of this enzyme can cause NIDDM. As a step toward understanding the molecular basis of glucokinase (GK) gene regulation, we assessed the structure and regulation of the human GK gene beta-cell-type promoter. The results of reporter gene analyses using HIT-T15 cells revealed that the gene promoter was comprised of multiple cis-acting elements, including two primarily important cis-motifs: a palindrome structure, hPal-1, and the insulin gene cis-motif A element-like hUPE3. While both elements were bound specifically by nuclear proteins, it was the homeodomain-containing transcription factor insulin promoter factor 1 (IPF1)/STF-1/PDX-1 that bound to the hUPE3 site: IPF1, when expressed in CHO-K1 cells, became bound to the hUPE3 site and activated transcription.
Publications: 1 Organism: Homo Sapiens
+ GCKdown-regulates quantity img/direct_inhibition.png chemical modification α-D-glucose 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266458 Homo sapiens
pmid sentence
Hexokinase catalyzes the phosphorylation of glucose to G6P, using ATP as a phosphoryl donor.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
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