| + |
GSK3B | up-regulates activity 
phosphorylation
|
USF1 |
0.291 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276354 |
Ser186 |
APRTHPYsPKSEAPR |
Homo sapiens |
T-98G Cell |
| pmid |
sentence |
| 21873430 |
Both MITF and USF1 were activated by glycogen synthase kinase (GSK) 3, with GSK3 phosphorylation sites on USF1 identified as the previously described activating site threonine 153 as well as serine 186. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276355 |
Thr153 |
EALLGQAtPPGTGQF |
Homo sapiens |
|
| pmid |
sentence |
| 21873430 |
Both MITF and USF1 were activated by glycogen synthase kinase (GSK) 3, with GSK3 phosphorylation sites on USF1 identified as the previously described activating site threonine 153 as well as serine 186. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
USF1 |
0.533 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185572 |
Thr153 |
EALLGQAtPPGTGQF |
Homo sapiens |
|
| pmid |
sentence |
| 19389701 |
Following uv irradiation, usf-1 is phosphorylated by the p38 stress-activated kinase on threonine 153 and directly up-regulates expression of the pomc, mc1r, tyr, tyrp-1 and dct genes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
USF1 | up-regulates quantity by expression 
transcriptional regulation
|
GATA5 |
0.341 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255596 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22625849 |
The present study provides the first evidence that USF1 activates GATA5 gene expression through the E-box motif and suggests a potential mechanism (disruption of the E-box) by which GATA5 promoter methylation reduces GATA5 expression in cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USF1 | up-regulates quantity by expression
transcriptional regulation
|
ADAM10 |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259837 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28624438 |
The promoter region of ADAM10 contains several transcription factor binding sites that can stimulate its transcription. These include binding sites for transcription factors SP1 and USF, and the spliced form of the X-box binding protein (XBP)-1 as well as a retinoic acid-responsive element |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USF1 | up-regulates quantity by expression
transcriptional regulation
|
Hexokinase |
0.294 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267797 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 9677331 |
Cotransfection of an expression plasmid encoding USF1 into HepG2 hepatoma cells resulted in the activation of the glucokinase promoter, dependent on the integrity of the P2 element |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270263 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 9677331 |
Cotransfection of an expression plasmid encoding USF1 into HepG2 hepatoma cells resulted in the activation of the glucokinase promoter, dependent on the integrity of the P2 element |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
USF1 | up-regulates quantity by expression
transcriptional regulation
|
GCK |
0.294 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255597 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9677331 |
Cotransfection of an expression plasmid encoding USF1 into HepG2 hepatoma cells resulted in the activation of the glucokinase promoter, dependent on the integrity of the P2 element |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USF1 | up-regulates activity
binding
|
JMJD1C |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265167 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32034158 |
We show that, by direct interaction with USF-1, JMJD1C is recruited to lipogenic promoters. We also show that JMJD1C is phosphorylated at T505 by mammalian target of rapamyci (mTOR) to be recruited to lipogenic genes in response to insulin/feeding. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Liver |
| + |
GTF2I | up-regulates activity
binding
|
USF1 |
0.503 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268538 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21282467 |
TFII-I has been shown to interact with USF and to associate with either E-box elements or initiator sequences to activate gene transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USF1 | up-regulates quantity by expression
transcriptional regulation
|
CEBPA |
0.323 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255702 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7862113 |
Our studies show that the human C/EBPa protein stimulates USF to bind to a USF consensus element within C/EBPa promoter and activates it by two- to threefold.The mechanism by which C/EBPa enhances USF binding and transactivation is currently under study. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USF1 | up-regulates quantity by expression
transcriptional regulation
|
FMR1 |
0.32 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254882 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11058604 |
We have also shown that USF1, USF2, and alpha-Pal/Nrf-1 are the major transcription factors that bind the promoter in brain and testis extracts and suggest that elevated levels of these factors account in part for elevated FMR1 expression in these organs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Testis, Brain |
| + |
USF1 | up-regulates quantity by expression
transcriptional regulation
|
CBS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254814 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12427542 |
We previously described essential transactivating roles for specificity protein 1 (Sp1), Sp3, nuclear factor Y (NF-Y), and USF-1 in the regulation of the CBS-1b promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USF1 | up-regulates quantity by expression
transcriptional regulation
|
S100A6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255598 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11118618 |
The results indicate that USF1 binds to an E-box sequence of the calcyclin gene promoter and enhances its transcription activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USF1 | up-regulates quantity by expression
transcriptional regulation
|
MYH9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-222554 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11467950 |
we have focused on element F of the NMHC-A gene. We have identified and characterized the factors which are capable of binding to element F. The basic helix_loop_helix leucine zipper (bHLH-LZ) proteins, TFEC-l and -s, which are alternatively spliced isoforms, TFE3, USF1, and USF2 have all been found to bind to element F with different binding activities and with different transcriptional activation potencies. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKDC | up-regulates
phosphorylation
|
USF1 |
0.297 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184849 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19303849 |
Feeding induces the recruitment of dna-pk to usf-1 and its phosphorylation, which then allows recruitment of p/caf, resulting in usf-1 acetylation and fas promoter activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPA | up-regulates activity
binding
|
USF1 |
0.323 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255701 |
|
|
Homo sapiens |
HEP-3B2 Cell |
| pmid |
sentence |
| 7862113 |
Our studies show that the human C/EBPa protein stimulates USF to bind to a USF consensus element within C/EBPa promoter and activates it by two- to threefold.The mechanism by which C/EBPa enhances USF binding and transactivation is currently under study. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USF1 | up-regulates quantity by expression
transcriptional regulation
|
B2M |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254655 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12480693 |
Here we show that upstream stimulatory factor 1 (USF1) and USF2 bind to the E box and regulate beta(2)m transactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USF1 | up-regulates quantity by expression
transcriptional regulation
|
POMC |
0.25 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185575 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19389701 |
Following uv irradiation, usf-1 is phosphorylated by the p38 stress-activated kinase on threonine 153 and directly up-regulates expression of the pomc, mc1r, tyr, tyrp-1 and dct genes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USF1 | up-regulates quantity by expression
transcriptional regulation
|
CTSD |
0.386 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255595 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 9731700 |
Overexpression of cathepsin D (CD), a ubiquitous lysosomal protease, is closely associated with a poor clinical outcome for patients with breast cancer. Estrogen greatly induces transcription of the CD gene in estrogen receptor (ER)-positive breast cancer cells. These experiments suggest a model for ER stimulation of the CD promoter in which recruitment of USF-1/2 to the promoter is required for activation of transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USF1 | down-regulates activity 
binding
|
FOSL1 |
0.479 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240975 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9160889 |
USF specifically interacts with Fra1. USF was repressing this modest Fra1 transactivation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
USF1
- 
- 