| + |
α-D-glucose | up-regulates quantity 
precursor of
|
alpha-D-glucose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266450 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Hexokinase catalyzes the phosphorylation of glucose to G6P, using ATP as a phosphoryl donor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycogenesis, Glycogenolysis, Glycolysis and Gluconeogenesis |
| + |
PGM1 | down-regulates quantity 
chemical modification
|
alpha-D-glucose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267932 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32898648 |
Human PGM1 deficiency is an inborn error of metabolism (OMIM: 614921), affecting cellular glucose homeostasis, the storage of glucose as glycogen, and the N-glycosylation of proteins. Like other PGM enzymes, the human protein catalyzes the Mg2+-dependent interconversion of glucose 1-phosphate (G1P) and glucose 6-phosphate (G6P). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycogenesis, Glycogenolysis |
| + |
GPI | down-regulates quantity
chemical modification
|
alpha-D-glucose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266461 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Glucose 6-phosphate isomerase (GPI) catalyzes the interconversion of G6P into fructose-6-phosphate (F6P) in the second step of the Embden-Meyerhof pathway (Figure 1). As a result of this reversible reaction, products of the hexose-monophosphate shunt can be recycled to G6P. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
G6PC2 | down-regulates quantity
chemical modification
|
alpha-D-glucose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266583 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12093795 |
Glucose-6-phosphatase (G6Pase), a key enzyme in glucose homeostasis, is anchored to the endoplasmic reticulum by nine transmembrane helices. The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His(119), Arg(170), and His(176). During catalysis, a His residue in G6Pase becomes phosphorylated generating an enzyme-phosphate intermediate. Glucose-6-phosphatase (G6Pase,1 EC 3.1.3.9), a key enzyme in glucose homeostasis, catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and phosphate, the terminal steps in gluconeogenesis and glycogenolysis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
alpha-D-glucose 6-phosphate(2-) | up-regulates quantity
precursor of
|
β-D-fructose 6-phosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266460 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Glucose 6-phosphate isomerase (GPI) catalyzes the interconversion of G6P into fructose-6-phosphate (F6P) in the second step of the Embden-Meyerhof pathway (Figure 1). As a result of this reversible reaction, products of the hexose-monophosphate shunt can be recycled to G6P. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis, Pentose phosphate pathway |
| + |
Hexokinase | up-regulates quantity
chemical modification
|
alpha-D-glucose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266449 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Hexokinase catalyzes the phosphorylation of glucose to G6P, using ATP as a phosphoryl donor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycogenesis, Glycolysis and Gluconeogenesis |
| + |
G6PD | down-regulates quantity
chemical modification
|
alpha-D-glucose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267050 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24769394 |
G6PD catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconate and concomitantly reduces NADP+ to NADPH, which is the rate-limiting and primary control step of the NADPH-generating portion in the PPP. Thus, G6PD acts as a guardian of cellular redox potential during oxidative stress |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Pentose phosphate pathway |
| + |
alpha-D-glucose 1-phosphate(2-) | up-regulates quantity
precursor of
|
alpha-D-glucose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267935 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32898648 |
Human PGM1 deficiency is an inborn error of metabolism (OMIM: 614921), affecting cellular glucose homeostasis, the storage of glucose as glycogen, and the N-glycosylation of proteins. Like other PGM enzymes, the human protein catalyzes the Mg2+-dependent interconversion of glucose 1-phosphate (G1P) and glucose 6-phosphate (G6P). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycogenesis, Glycogenolysis |
| + |
PGM2 | down-regulates quantity
chemical modification
|
alpha-D-glucose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268116 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32898648 |
Human PGM1 deficiency is an inborn error of metabolism (OMIM: 614921), affecting cellular glucose homeostasis, the storage of glucose as glycogen, and the N-glycosylation of proteins. Like other PGM enzymes, the human protein catalyzes the Mg2+-dependent interconversion of glucose 1-phosphate (G1P) and glucose 6-phosphate (G6P). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycogenesis, Glycogenolysis, Pentose phosphate pathway |
| + |
alpha-D-glucose 6-phosphate(2-) | up-regulates quantity
precursor of
|
α-D-glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266577 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12093795 |
Glucose-6-phosphatase (G6Pase), a key enzyme in glucose homeostasis, is anchored to the endoplasmic reticulum by nine transmembrane helices. The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His(119), Arg(170), and His(176). During catalysis, a His residue in G6Pase becomes phosphorylated generating an enzyme-phosphate intermediate. Glucose-6-phosphatase (G6Pase,1 EC 3.1.3.9), a key enzyme in glucose homeostasis, catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and phosphate, the terminal steps in gluconeogenesis and glycogenolysis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycogenesis, Glycogenolysis, Glycolysis and Gluconeogenesis |
| + |
HK1 | up-regulates quantity
chemical modification
|
alpha-D-glucose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266445 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Hexokinase catalyzes the phosphorylation of glucose to G6P, using ATP as a phosphoryl donor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
G6P | down-regulates quantity
chemical modification
|
alpha-D-glucose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266571 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12093795 |
Glucose-6-phosphatase (G6Pase), a key enzyme in glucose homeostasis, is anchored to the endoplasmic reticulum by nine transmembrane helices. The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His(119), Arg(170), and His(176). During catalysis, a His residue in G6Pase becomes phosphorylated generating an enzyme-phosphate intermediate. Glucose-6-phosphatase (G6Pase,1 EC 3.1.3.9), a key enzyme in glucose homeostasis, catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and phosphate, the terminal steps in gluconeogenesis and glycogenolysis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
HK2 | up-regulates quantity
chemical modification
|
alpha-D-glucose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266446 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Hexokinase catalyzes the phosphorylation of glucose to G6P, using ATP as a phosphoryl donor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
G6PC1 | down-regulates quantity
chemical modification
|
alpha-D-glucose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266582 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12093795 |
Glucose-6-phosphatase (G6Pase), a key enzyme in glucose homeostasis, is anchored to the endoplasmic reticulum by nine transmembrane helices. The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His(119), Arg(170), and His(176). During catalysis, a His residue in G6Pase becomes phosphorylated generating an enzyme-phosphate intermediate. Glucose-6-phosphatase (G6Pase,1 EC 3.1.3.9), a key enzyme in glucose homeostasis, catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and phosphate, the terminal steps in gluconeogenesis and glycogenolysis |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266568 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12093795 |
Glucose-6-phosphatase (G6Pase), a key enzyme in glucose homeostasis, is anchored to the endoplasmic reticulum by nine transmembrane helices. The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His(119), Arg(170), and His(176). During catalysis, a His residue in G6Pase becomes phosphorylated generating an enzyme-phosphate intermediate. Glucose-6-phosphatase (G6Pase,1 EC 3.1.3.9), a key enzyme in glucose homeostasis, catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and phosphate, the terminal steps in gluconeogenesis and glycogenolysis |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
alpha-D-glucose 6-phosphate(2-) | up-regulates quantity
precursor of
|
6-O-phosphono-D-glucono-1,5-lactone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267049 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24769394 |
G6PD catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconate and concomitantly reduces NADP+ to NADPH, which is the rate-limiting and primary control step of the NADPH-generating portion in the PPP. Thus, G6PD acts as a guardian of cellular redox potential during oxidative stress |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Pentose phosphate pathway |
| + |
GCK | up-regulates quantity
chemical modification
|
alpha-D-glucose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266448 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Hexokinase catalyzes the phosphorylation of glucose to G6P, using ATP as a phosphoryl donor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
G6PC3 | down-regulates quantity
chemical modification
|
alpha-D-glucose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266570 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12093795 |
Glucose-6-phosphatase (G6Pase), a key enzyme in glucose homeostasis, is anchored to the endoplasmic reticulum by nine transmembrane helices. The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His(119), Arg(170), and His(176). During catalysis, a His residue in G6Pase becomes phosphorylated generating an enzyme-phosphate intermediate. Glucose-6-phosphatase (G6Pase,1 EC 3.1.3.9), a key enzyme in glucose homeostasis, catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and phosphate, the terminal steps in gluconeogenesis and glycogenolysis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HK3 | up-regulates quantity
chemical modification
|
alpha-D-glucose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266447 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Hexokinase catalyzes the phosphorylation of glucose to G6P, using ATP as a phosphoryl donor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
PGM2 | up-regulates quantity
chemical modification
|
alpha-D-glucose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267934 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32898648 |
Human PGM1 deficiency is an inborn error of metabolism (OMIM: 614921), affecting cellular glucose homeostasis, the storage of glucose as glycogen, and the N-glycosylation of proteins. Like other PGM enzymes, the human protein catalyzes the Mg2+-dependent interconversion of glucose 1-phosphate (G1P) and glucose 6-phosphate (G6P). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycogenesis, Glycogenolysis, Pentose phosphate pathway |
| + |
alpha-D-glucose 6-phosphate(2-) | up-regulates quantity
precursor of
|
alpha-D-glucose 1-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267936 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32898648 |
Human PGM1 deficiency is an inborn error of metabolism (OMIM: 614921), affecting cellular glucose homeostasis, the storage of glucose as glycogen, and the N-glycosylation of proteins. Like other PGM enzymes, the human protein catalyzes the Mg2+-dependent interconversion of glucose 1-phosphate (G1P) and glucose 6-phosphate (G6P). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycogenesis, Glycogenolysis |
| + |
PGM1 | up-regulates quantity
chemical modification
|
alpha-D-glucose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267930 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32898648 |
Human PGM1 deficiency is an inborn error of metabolism (OMIM: 614921), affecting cellular glucose homeostasis, the storage of glucose as glycogen, and the N-glycosylation of proteins. Like other PGM enzymes, the human protein catalyzes the Mg2+-dependent interconversion of glucose 1-phosphate (G1P) and glucose 6-phosphate (G6P). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycogenesis, Glycogenolysis |
3.0
alpha-D-glucose 6-phosphate(2-)