Relation Results

Summary

Name GRK3
Full Name Beta-adrenergic receptor kinase 2
Synonyms Beta-ARK-2, G-protein-coupled receptor kinase 3 | BARK2, GRK3
Primary ID P35626
Links - -
Type protein
Relations 10
Function Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.

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Type: Score: Layout: SPV 
0.20.20.20.2GRK3TBXA2RCCR5BDKRB2OPRM1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ GRK3down-regulates activity img/direct_inhibition.png phosphorylation TBXA2R (isoform 2) 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-274090 Ser239 AQQRPRDsEVEMMAQ Homo sapiens
pmid sentence
 These data suggest a model whereby agonist-induced PKC phosphorylation of Ser(145) partially impairs TPbeta signalling while GRK2/3 phosphorylation at both Ser(239) and Ser(357) within its IC(3) and C-tail domains, respectively, sterically inhibits G-protein coupling, profoundly desensitizing signalling, and promotes beta-arrestin association and, in turn, facilitates TPbeta internalization.
Identifier Residue Sequence Organism Cell Line
SIGNOR-274091 Ser357 RLPGSSDsRASASRA Homo sapiens
pmid sentence
 These data suggest a model whereby agonist-induced PKC phosphorylation of Ser(145) partially impairs TPbeta signalling while GRK2/3 phosphorylation at both Ser(239) and Ser(357) within its IC(3) and C-tail domains, respectively, sterically inhibits G-protein coupling, profoundly desensitizing signalling, and promotes beta-arrestin association and, in turn, facilitates TPbeta internalization.
Publications: 2 Organism: Homo Sapiens
+ GRK3down-regulates activity img/direct_inhibition.png phosphorylation CCR5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-251463 Ser336 QEAPERAsSVYTRST Chlorocebus aethiops COS-7 Cell
pmid sentence
Serine residues at positions 336, 337, 342, and 349 represent GRK phosphorylation sites on CCR5. CCR5 phosphorylation and desensitization through a GRK-mediated mechanism
Identifier Residue Sequence Organism Cell Line
SIGNOR-251464 Ser337 EAPERASsVYTRSTG Chlorocebus aethiops COS-7 Cell
pmid sentence
Serine residues at positions 336, 337, 342, and 349 represent GRK phosphorylation sites on CCR5. CCR5 phosphorylation and desensitization through a GRK-mediated mechanism
Identifier Residue Sequence Organism Cell Line
SIGNOR-249675 Ser342 ASSVYTRsTGEQEIS Chlorocebus aethiops COS-7 Cell
pmid sentence
Phosphoamino acid analysis revealed that RANTES-induced CCR5 phosphorylation selectively occurs on serine residues. Our findings with receptor mutants indicate that serine residues at positions 336, 337, 342, and 349 represent GRK phosphorylation sites on CCR5.
Identifier Residue Sequence Organism Cell Line
SIGNOR-249679 Ser349 STGEQEIsVGL Chlorocebus aethiops COS-7 Cell
pmid sentence
Phosphoamino acid analysis revealed that RANTES-induced CCR5 phosphorylation selectively occurs on serine residues. Our findings with receptor mutants indicate that serine residues at positions 336, 337, 342, and 349 represent GRK phosphorylation sites on CCR5.
Publications: 4 Organism: Chlorocebus Aethiops
+ GRK3down-regulates activity img/direct_inhibition.png phosphorylation BDKRB2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-251460 Ser366 EPIQMENsMGTLRTS Homo sapiens HEK-293 Cell
pmid sentence
Ligand-induced phosphorylation is found at Ser339 and Ser346/Ser348 that could be executed by several G protein-coupled receptor kinases. 32P labeling of peptide 3 containing pS346/pS348 was enhanced 1.5–3-fold as compared with mock-transfected cells in the order GRK6 < GRK5 < GRK2 < GRK4α < GRK3. several endogenous GRKs may phosphorylate the B2R and that the various GRKs, even without apparent effect on total GPCR phosphorylation levels, may induce distinct phosphorylation patterns with possible functional consequences for receptor desensitization and sequestration.
Identifier Residue Sequence Organism Cell Line
SIGNOR-249658 Ser373 SMGTLRTsISVERQI Homo sapiens HEK-293 Cell
pmid sentence
...expression of GRK4Ž drastically increased the basal level of32P incorporation into B2R.[€]a clustered phosphorylation around Ser(346) is necessary for desensitization of the B2 receptor-induced phospholipase C activation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-251462 Ser375 GTLRTSIsVERQIHK Homo sapiens HEK-293 Cell
pmid sentence
Ligand-induced phosphorylation is found at Ser339 and Ser346/Ser348 that could be executed by several G protein-coupled receptor kinases. 32P labeling of peptide 3 containing pS346/pS348 was enhanced 1.5–3-fold as compared with mock-transfected cells in the order GRK6 < GRK5 < GRK2 < GRK4α < GRK3. several endogenous GRKs may phosphorylate the B2R and that the various GRKs, even without apparent effect on total GPCR phosphorylation levels, may induce distinct phosphorylation patterns with possible functional consequences for receptor desensitization and sequestration.
Publications: 3 Organism: Homo Sapiens
+ GRK3down-regulates activity img/direct_inhibition.png phosphorylation OPRM1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-247915 Thr182 VKALDFRtPRNAKII Xenopus laevis
pmid sentence
These results demonstrate that the T180A mutation probably blocks GRK3- and arr3-mediated desensitization of MOR by preventing a critical agonist-dependent receptor phosphorylation and suggest a novel GRK3 site of regulation not yet described for other G-protein-coupled receptors
Publications: 1 Organism: Xenopus Laevis
Tissue: Primary Oocyte
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