Relation Results

Summary

Name TBXA2R
Full Name Isoform 2 of Thromboxane A2 receptor
Synonyms TXA2-R, Prostanoid TP receptor |
Primary ID P21731-2
Links - -
Type protein
Relations 5
Function Inhibits adenylyl cyclase. {ECO:0000269|PubMed:8613548}.

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Type: Score: Layout: SPV 
0.5140.20.2PRKCATBXA2RGRK2GRK3

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PRKCAdown-regulates activity img/direct_inhibition.png phosphorylation TBXA2R (isoform 2) 0.514
Identifier Residue Sequence Organism Cell Line
SIGNOR-274092 Ser145 FSRPAVAsQRRAWAT Homo sapiens
pmid sentence
 These data suggest a model whereby agonist-induced PKC phosphorylation of Ser(145) partially impairs TPbeta signalling while GRK2/3 phosphorylation at both Ser(239) and Ser(357) within its IC(3) and C-tail domains, respectively, sterically inhibits G-protein coupling, profoundly desensitizing signalling, and promotes beta-arrestin association and, in turn, facilitates TPbeta internalization.
Publications: 1 Organism: Homo Sapiens
+ GRK2down-regulates activity img/direct_inhibition.png phosphorylation TBXA2R (isoform 2) 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-274088 Ser239 AQQRPRDsEVEMMAQ Homo sapiens
pmid sentence
 These data suggest a model whereby agonist-induced PKC phosphorylation of Ser(145) partially impairs TPbeta signalling while GRK2/3 phosphorylation at both Ser(239) and Ser(357) within its IC(3) and C-tail domains, respectively, sterically inhibits G-protein coupling, profoundly desensitizing signalling, and promotes beta-arrestin association and, in turn, facilitates TPbeta internalization.
Identifier Residue Sequence Organism Cell Line
SIGNOR-274089 Ser357 RLPGSSDsRASASRA Homo sapiens
pmid sentence
 These data suggest a model whereby agonist-induced PKC phosphorylation of Ser(145) partially impairs TPbeta signalling while GRK2/3 phosphorylation at both Ser(239) and Ser(357) within its IC(3) and C-tail domains, respectively, sterically inhibits G-protein coupling, profoundly desensitizing signalling, and promotes beta-arrestin association and, in turn, facilitates TPbeta internalization.
Publications: 2 Organism: Homo Sapiens
+ GRK3down-regulates activity img/direct_inhibition.png phosphorylation TBXA2R (isoform 2) 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-274090 Ser239 AQQRPRDsEVEMMAQ Homo sapiens
pmid sentence
 These data suggest a model whereby agonist-induced PKC phosphorylation of Ser(145) partially impairs TPbeta signalling while GRK2/3 phosphorylation at both Ser(239) and Ser(357) within its IC(3) and C-tail domains, respectively, sterically inhibits G-protein coupling, profoundly desensitizing signalling, and promotes beta-arrestin association and, in turn, facilitates TPbeta internalization.
Identifier Residue Sequence Organism Cell Line
SIGNOR-274091 Ser357 RLPGSSDsRASASRA Homo sapiens
pmid sentence
 These data suggest a model whereby agonist-induced PKC phosphorylation of Ser(145) partially impairs TPbeta signalling while GRK2/3 phosphorylation at both Ser(239) and Ser(357) within its IC(3) and C-tail domains, respectively, sterically inhibits G-protein coupling, profoundly desensitizing signalling, and promotes beta-arrestin association and, in turn, facilitates TPbeta internalization.
Publications: 2 Organism: Homo Sapiens
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