| + |
GRK3 | down-regulates activity 
phosphorylation
|
CCR5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251463 |
Ser336 |
QEAPERAsSVYTRST |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10085131 |
Serine residues at positions 336, 337, 342, and 349 represent GRK phosphorylation sites on CCR5. CCR5 phosphorylation and desensitization through a GRK-mediated mechanism |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251464 |
Ser337 |
EAPERASsVYTRSTG |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10085131 |
Serine residues at positions 336, 337, 342, and 349 represent GRK phosphorylation sites on CCR5. CCR5 phosphorylation and desensitization through a GRK-mediated mechanism |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249675 |
Ser342 |
ASSVYTRsTGEQEIS |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10085131 |
Phosphoamino acid analysis revealed that RANTES-induced CCR5 phosphorylation selectively occurs on serine residues. Our findings with receptor mutants indicate that serine residues at positions 336, 337, 342, and 349 represent GRK phosphorylation sites on CCR5. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249679 |
Ser349 |
STGEQEIsVGL |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10085131 |
Phosphoamino acid analysis revealed that RANTES-induced CCR5 phosphorylation selectively occurs on serine residues. Our findings with receptor mutants indicate that serine residues at positions 336, 337, 342, and 349 represent GRK phosphorylation sites on CCR5. |
|
| Publications: |
4 |
Organism: |
Chlorocebus Aethiops |
| + |
CCL5 | up-regulates activity 
binding
|
CCR5 |
0.936 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277726 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 38339310 |
CCL5, also known RANTES (regulated on activation, normal T cell expressed and secreted), is a potent chemoattractant for a variety of leukocytes, including T cells, mono- cytes, NK cells, and basophils, signaling via the CCR1, CCR3, and CCR5 cell surface receptors [59]. Among these receptors, CCL5 has the highest affinity for CCR5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Vicriviroc Malate | down-regulates
chemical inhibition
|
CCR5 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-207657 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCL4 | up-regulates activity
binding
|
CCR5 |
0.857 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255116 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20219869 |
The investigators showed that myoblasts constitutively express receptors for CCL2 (CCR2), CCL3 (CCR1 and CCR5), and CCL4 (CCR5), and that stimulation with either CCL2 or CCL4 was sufficient to promote myoblast proliferation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CCL3 | up-regulates activity
binding
|
CCR5 |
0.739 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251724 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15075201 |
The purpose of this study was to determine whether certain chemokines, which are highly expressed in injured skeletal muscle, are involved in the repair and functional recovery of the muscle after traumatic injury. In wild-type control mice, mRNA transcripts of macrophage inflammatory protein (MIP)-1, MIP-1, and monocyte chemoattractant protein (MCP)-1 as well as their major receptors, CCR5 and CCR2, increased after freeze injury and gradu- ally returned to control (uninjured) levels by 14 days. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255115 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20219869 |
The investigators showed that myoblasts constitutively express receptors for CCL2 (CCR2), CCL3 (CCR1 and CCR5), and CCL4 (CCR5), and that stimulation with either CCL2 or CCL4 was sufficient to promote myoblast proliferation. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
CCR5 | up-regulates activity
phosphorylation
|
ERK1/2 |
0.329 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255119 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20219869 |
The investigators showed that myoblasts constitutively express receptors for CCL2 (CCR2), CCL3 (CCR1 and CCR5), and CCL4 (CCR5), and that stimulation with either CCL2 or CCL4 was sufficient to promote myoblast proliferation. Furthermore, stimulation of myoblasts with CCL2, CCL3, or CCL4 was sufficient to induce phosphorylation and activation of ERK1/2. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
maraviroc | down-regulates
chemical inhibition
|
CCR5 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-194248 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CCR5
- 
- 