Summary

Name CASR
Full Name Extracellular calcium-sensing receptor
Synonyms CaSR, Parathyroid cell calcium-sensing receptor 1, PCaR1 | GPRC2A, PCAR1
Primary ID P41180
Links - -
Type protein
Relations 4
Function G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation CASR 0.358
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CASR 0.322
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CASR 0.478
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CASR 0.391
Publications: 1 Organism: Homo Sapiens