Relation Results

Summary

Name CASR
Full Name Extracellular calcium-sensing receptor
Synonyms CaSR, Parathyroid cell calcium-sensing receptor 1, PCaR1 | GPRC2A, PCAR1
Primary ID P41180
Links - -
Type protein
Relations 4
Function G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeosta ...
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Type: Score: Layout: SPV 
0.3580.3240.4680.39PRKCACASRPRKCBGCM2RNF19A

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PRKCAdown-regulates img/direct_inhibition.png phosphorylation CASR 0.358
Identifier Residue Sequence Organism Cell Line
SIGNOR-170334 Thr888 FKVAARAtLRRSNVS Homo sapiens
pmid sentence
Casr(t888) is a protein kinase c (pkc) phosphorylation site in the receptor's intracellular domain that has previously been identified as a critical negative regulator of casr downstream signaling in vitro, thus, casr(t888) represents a functionally important, inhibitory phosphorylation site that contributes to the control of pth secretion.
Publications: 1 Organism: Homo Sapiens
+ PRKCBdown-regulates activity img/direct_inhibition.png phosphorylation CASR 0.324
Identifier Residue Sequence Organism Cell Line
SIGNOR-249176 Thr888 FKVAARAtLRRSNVS Homo sapiens HEK-293 Cell
pmid sentence
Expression of a mutant CaR in which the major PKC phosphorylation site is altered by substitution of alanine for threonine (T888A) eliminated oscillatory behavior, producing [Ca(2+)](i) responses almost identical to those produced by the wild type CaR exposed to PKC inhibitors. These results support a model in which phosphorylation of the CaR at the inhibitory threonine 888 by PKC provides the negative feedback needed to cause [Ca(2+)](i) oscillations mediated by this receptor.
Publications: 1 Organism: Homo Sapiens
+ GCM2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CASR 0.468
Identifier Residue Sequence Organism Cell Line
SIGNOR-254199 Homo sapiens Parathyroid Hormone Secreting Cell
pmid sentence
we show that both promoters (P1 and P2) of the calcium-sensing receptor (CASR) gene, a differentiation marker for the parathyroid gland, are transactivated by wild-type GCM2.
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ RNF19Adown-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CASR 0.39
Identifier Residue Sequence Organism Cell Line
SIGNOR-271456 Homo sapiens HEK-293 Cell
pmid sentence
Coexpression with dorfin decreased the amount of total CaR protein and increased CaR ubiquitination, whereas a dominant negative fragment of dorfin had opposite effects. dorfin-mediated proteasomal degradation of immature CaR occurs from the endoplasmic reticulum. Because endogenous CaR in Madin-Darby canine kidney cells is also subject to degradation from the endoplasmic reticulum, dorfin-mediated ubiquitination may contribute to a general mechanism for CaR quality control during biosynthesis.
Publications: 1 Organism: Homo Sapiens
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