Relation Results

Name	RNF19A
Full Name	E3 ubiquitin-protein ligase RNF19A
Synonyms	Double ring-finger protein, Dorfin, RING finger protein 19A, p38 \| RNF19
Primary ID	Q9NV58
Links	- -
Type	protein
Relations	3
Function	E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.