4.0
Summary
| Name |  MTHFRView Modifications |
| Full Name | Methylenetetrahydrofolate reductase |
| Synonyms | MTHR_HUMAN | |
| Primary ID | P42898 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Pathways | One-carbon Metabolism |
| Function | Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CyclinB/CDK1 | down-regulates activity 
phosphorylation
|
MTHFR | 0.333 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MTHFR | up-regulates quantity 
chemical modification
|
(6S)-5-methyltetrahydrofolate(2-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | One-carbon Metabolism | |||
| + | MTHFR | up-regulates 
|
Chromatine_condensation | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | One-carbon Metabolism | |||
| + | MTHFR | down-regulates quantity
chemical modification
|
(6R)-5,10-methylenetetrahydrofolate(2-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | One-carbon Metabolism | |||
| + | JUN | up-regulates
|
MTHFR | 0.272 |
| Publications: | 1 | Organism: | Homo Sapiens | |