| + |
CASP3 | up-regulates 
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-66860 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10200555 |
Caspase-3 is required for blebbing, chromatin condensation and dna fragmentation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
HMGN1 | down-regulates 
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262989 |
|
|
in vitro |
|
| pmid |
sentence |
| 12213813 |
In vitro, binding of HMGN1 proteins to the nucleosomes reduces chromatin compaction and promotes overall accessibility to the nucleosomes |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
Nucleosome_H3.3 variant | up-regulates
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263878 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15776021 |
Variant histone H3.3 is incorporated into nucleosomes by a mechanism that does not require DNA replication and has also been implicated as a potential mediator of epigenetic memory of active transcriptional states. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Nucleosome_H2A.Z.1 variant | up-regulates
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263713 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24311584 |
In the nucleosome, two of each of the histones H2A, H2B, H3 and H4 form the histone octamer and about 145–147 base pairs of DNA are wrapped around it . The histone H2A.Z variant is widely conserved among eukaryotes. Two isoforms, H2A.Z.1 and H2A.Z.2, have been identified in vertebrates and may have distinct functions in cell growth and gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MBD3/NuRD complex | up-regulates
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263860 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27098840 |
The NuRD complex is a multi-protein transcriptional corepressor that couples histone deacetylase and ATP-dependent chromatin remodelling activities.In humans, an assembly of proteins called the NuRD complex makes chromatin more compact by removing acetyl groups from nucleosomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Nucleosome_H2A.Z.2 variant | up-regulates
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263714 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24311584 |
In the nucleosome, two of each of the histones H2A, H2B, H3 and H4 form the histone octamer and about 145–147 base pairs of DNA are wrapped around it . The histone H2A.Z variant is widely conserved among eukaryotes. Two isoforms, H2A.Z.1 and H2A.Z.2, have been identified in vertebrates and may have distinct functions in cell growth and gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Nucleosome_H3.1t variant | up-regulates
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263728 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20498094 |
A histone H3 variant, H3T, is highly expressed in the testis, suggesting that it may play an important role in the chromatin reorganization required for meiosis and/or spermatogenesis. In the present study, we found that the nucleosome containing human H3T is significantly unstable both in vitro and in vivo, as compared to the conventional nucleosome containing H3.1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDLBP | up-regulates
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266694 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33941620 |
Vigilin (Vgl1) is essential for heterochromatin formation, chromosome segregation, and mRNA stability and is associated with autism spectrum disorders and cancer: vigilin, for example, can suppress proto-oncogene c-fms expression in breast cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MTHFR | up-regulates
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263889 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 24769206 |
MTHFR promotes heterochromatin maintenance at the centromeric region. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | One-carbon Metabolism |
| + |
MBD2/NuRD complex | up-regulates
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263859 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27098840 |
The NuRD complex is a multi-protein transcriptional corepressor that couples histone deacetylase and ATP-dependent chromatin remodelling activities.In humans, an assembly of proteins called the NuRD complex makes chromatin more compact by removing acetyl groups from nucleosomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CENP-A nucleosome | up-regulates
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263703 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20566683 |
Centromeres contain specialized nucleosomes in which histone H3 is replaced by the histone variant centromere protein A (CENP-A). CENP-A nucleosomes are thought to act as an epigenetic mark that specifies centromere identity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MBD5 | up-regulates
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266773 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20700456 |
The human proteins MBD5 and MBD6 associate with heterochromatin but they do not bind methylated DNA.Our data suggest that MBD5 and MBD6 are unlikely to be methyl-binding proteins, yet they may contribute to the formation or function of heterochromatin. One isoform of MBD5 is highly expressed in oocytes, which suggests a possible role in epigenetic reprogramming after fertilization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SAGA complex | down-regulates
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269569 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15970593 |
Transcription initiation is a major regulatory step in eukaryotic gene expression. Co-activators establish transcriptionally competent promoter architectures and chromatin signatures to allow the formation of the pre-initiation complex (PIC), comprising RNA polymerase II (Pol II) and general transcription factors (GTFs).|this observation appears remarkably prevalent for chromatin-modifying and remodeling complexes. Here, we use the modular organization of the evolutionary conserved Spt-Ada-Gcn5 acetyltransferase (SAGA) complex as a paradigm to illustrate how co-activators share and combine a relatively limited set of functional tools. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Condensin II | up-regulates
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263913 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32445620 |
Human Condensin I and II Drive Extensive ATP-Dependent Compaction of Nucleosome-Bound DNA. the combined actions of both condensins contribute to formation of a nested-loop architecture necessary to achieve the highest level of chromosome compaction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Nucleosome_H3.1 variant | up-regulates
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263723 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21812398 |
The elemental repeating unit of chromatin is the nucleosome core particle (NCP), which consists of 146 base pairs of DNA wrapped in 1.65 left-handed superhelical turns around the histone octamer. The histone octamer comprises two each of the core histones, H2A, H2B, H3 and H4, which form two H2A/H2B dimers and an H3/H4 tetramer, respectively, in the NCP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZMIZ1 | up-regulates
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263938 |
|
|
Mus musculus |
T-cell Lymphoma Cell |
| pmid |
sentence |
| 26522984 |
Our data suggest that Zmiz1 and Notch1 cooperatively recruit each other to chromatin through direct interaction via the TPR resulting in a slight increase in activating histone marks and decrease of repressive histone marks. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CoREST-HDAC complex | up-regulates
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263861 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32101746 |
The CoREST complex is one of seven families of class I histone deacetylase complexes that have specialized physiological functions but are all thought to act as repressors of gene expression. CoREST is unique within these complexes in that it removes both acetyl and methyl modifications through the activity of its demethylase (LSD1) and deacetylase (HDAC1) enzymes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CERF | up-regulates
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263892 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15640247 |
CERF is an ATP-dependent chromatin remodeler. CERF comprises CECR2 and the ATP-dependent chromatin remodeler SNF2L, a mammalian ISWI ortholog expressed predominantly in the central nervous system. CERF is capable of remodeling chromatin in vitro and displays an ATP hydrolyzing activity that is stimulated by nucleosomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Central Nervous System |
| + |
ACIN1 | up-regulates
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70797 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10490026 |
Acinus induces apoptotic chromatin condensation after cleavage by caspase-3 without inducing dna fragmentation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | up-regulates
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256477 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10200555 |
Caspase-3 is required for blebbing, chromatin condensation and dna fragmentation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
Condensin I | up-regulates
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263907 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32445620 |
Human Condensin I and II Drive Extensive ATP-Dependent Compaction of Nucleosome-Bound DNA. the combined actions of both condensins contribute to formation of a nested-loop architecture necessary to achieve the highest level of chromosome compaction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Chromatine_condensation