Summary

Name SLC1A2
Full Name Excitatory amino acid transporter 2
Synonyms Glutamate/aspartate transporter II, Sodium-dependent glutamate/aspartate transporter 2, Solute carrier family 1 member 2 | EAAT2, GLT1
Primary ID P43004
Links - -
Type protein
Relations 4
Function Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:14506254, PubMed:15265858, PubMed:26690923). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ NHLRC1up-regulates activity img/direct-activation.png ubiquitination SLC1A2
Publications: 1 Organism: Homo Sapiens
+ NEDD4Ldown-regulates quantity img/direct_inhibition.png ubiquitination SLC1A2
Publications: 1 Organism: Homo Sapiens
+ SLC1A2up-regulates quantity img/direct-activation.png relocalization glutamic acid 0.8
Publications: 1 Organism: Homo Sapiens
+ CAV1down-regulates activity img/direct_inhibition.png binding SLC1A2 0.251
Publications: 1 Organism: Homo Sapiens