+ |
NOG | down-regulates activity
binding
|
GDF5 |
0.688 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252420 |
|
|
Homo sapiens |
|
pmid |
sentence |
21976273 |
Growth and differentiation factor 5 (GDF5), a member of the bone morphogenetic protein (BMP) family, is essential for cartilage, bone, and joint formation. Antagonists such as noggin counteract BMP signaling by covering the ligand's BMP type I (BMPRI) and type II (BMPRII, ActRII, ActRIIB) interaction sites. The mutation GDF5-S94N is located within the BMPRII interaction site, the so-called knuckle epitope, and was identified in patients suffering from multiple synostoses syndrome (SYNS). |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251865 |
|
|
Homo sapiens |
|
pmid |
sentence |
19956691 |
We identified two mutations (N445K,T) in patients with multiple synostosis syndrome (SYM1) in the BMP–related ligand GDF5. Residue N445, situated within overlapping receptor and antagonist interfaces, is highly conserved among the BMP family with the exception of BMP9 and BMP10, in which it is substituted with lysine. Like the mutant GDF5, both BMPs are insensitive to NOGGIN and show a high chondrogenic activity. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
GDF5 | up-regulates quantity by expression
transcriptional regulation
|
ID3 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251872 |
|
|
Homo sapiens |
Umbilical Vein Smooth Muscle |
pmid |
sentence |
16716349 |
GDF5 induces ID1 and ID3 in HUVSMC by a smad-dependent, MAPK-independent pathway. GDF5 binds to specific receptors, thereby inducing phosphorylation and translocation of smad1 to the nucleus where it is involved in the regulation of transcription. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
GDF5 | up-regulates quantity by expression
transcriptional regulation
|
ID1 |
0.285 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251871 |
|
|
Homo sapiens |
Umbilical Vein Smooth Muscle |
pmid |
sentence |
16716349 |
GDF5 induces ID1 and ID3 in HUVSMC by a smad-dependent, MAPK-independent pathway. GDF5 binds to specific receptors, thereby inducing phosphorylation and translocation of smad1 to the nucleus where it is involved in the regulation of transcription. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
GDF5 | up-regulates
|
Cartilage_development |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252418 |
|
|
Homo sapiens |
|
pmid |
sentence |
21976273 |
Growth and differentiation factor 5 (GDF5), a member of the bone morphogenetic protein (BMP) family, is essential for cartilage, bone, and joint formation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
GDF5 | up-regulates activity
binding
|
BMPR1B |
0.777 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-256483 |
|
|
Mus musculus |
|
pmid |
sentence |
15890363 |
In contrast to other members of the TGF-beta superfamily, GDF-5 shows a pronounced specificity in type I receptor interaction in cross-link experiments binding only to BMP receptor IB (BMPR-IB). In mice, deletion of either GDF-5 or BMPR-IB results in a similar phenotype, indicating that GDF-5 signaling is highly dependent on BMPR-IB. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
TRPS1 | down-regulates quantity by repression
transcriptional regulation
|
GDF5 |
0.311 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251866 |
|
|
Mus musculus |
Chondrogenic Cell |
pmid |
sentence |
18363966 |
Treatment of cells with Gdf5 enhanced Trps1 protein levels and phosphorylation of p38 mitogen-activated protein kinase (MAPK) in a dose-dependent manner. Nuclear translocation of Trps1 was also induced by Gdf5. These effects were blocked by a dominant negative form of activin-linked kinase 6 (dn-Alk6) and by SB203580, an inhibitor of the p38 MAPK pathway. Conversely, Gdf5 expression was suppressed by the over-expression of Trps1. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
GDF5 | up-regulates activity
relocalization
|
TRPS1 |
0.311 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251867 |
|
|
Mus musculus |
Chondrogenic Cell |
pmid |
sentence |
18363966 |
Treatment of cells with Gdf5 enhanced Trps1 protein levels and phosphorylation of p38 mitogen-activated protein kinase (MAPK) in a dose-dependent manner. Nuclear translocation of Trps1 was also induced by Gdf5. These effects were blocked by a dominant negative form of activin-linked kinase 6 (dn-Alk6) and by SB203580, an inhibitor of the p38 MAPK pathway. Conversely, Gdf5 expression was suppressed by the over-expression of Trps1. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
GDF5 | up-regulates
|
Ossification |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252419 |
|
|
Homo sapiens |
|
pmid |
sentence |
21976273 |
Growth and differentiation factor 5 (GDF5), a member of the bone morphogenetic protein (BMP) family, is essential for cartilage, bone, and joint formation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
IL1B | down-regulates quantity by repression
transcriptional regulation
|
GDF5 |
0.267 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251864 |
|
|
Homo sapiens |
Synoviocyte |
pmid |
sentence |
19818765 |
GDF-5 is suppressed by IL-1beta and enhances TGF-beta3-mediated chondrogenic differentiation in human rheumatoid fibroblast-like synoviocytes. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |