Summary

Name GDF5
Full Name Growth/differentiation factor 5
Synonyms GDF-5, Bone morphogenetic protein 14, BMP-14, Cartilage-derived morphogenetic protein 1, CDMP-1, Lipopolysaccharide-associated protein 4, LAP-4, LPS-associated protein 4, Radotermin | BMP14, CDMP1
Primary ID P43026
Links - -
Type protein
Relations 10
Pathways Myofiber: BMP
Function Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149, PubMed:21976273, PubMed:15530414, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205).

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png binding GDF5 0.688
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ID3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ID1 0.285
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Cartilage_development 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BMPR1B 0.777
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GDF5 0.311
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png relocalization TRPS1 0.311
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png Ossification 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GDF5 0.267
Publications: 1 Organism: Homo Sapiens