Summary

Name PAFAH1B1
Full Name Platelet-activating factor acetylhydrolase IB subunit beta
Synonyms Lissencephaly-1 protein, LIS-1, PAF acetylhydrolase 45 kDa subunit, PAF-AH 45 kDa subunit, PAF-AH alpha, PAFAH alpha | LIS1, MDCR, MDS, PAFAHA
Primary ID P43034
Links - -
Type protein
Relations 9
Function Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates to the PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (PubMed:22956769). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding NDEL1 0.839
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png Neuron_migration 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PAFAH1B1 0.2
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png binding CLIP1 0.785
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding PAFAH1B1 0.495
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DYNC1H1 0.882
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by stabilization img/direct-activation.png binding PAFAH1B1 0.455
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PAFAH1B1 0.496
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Cerebral_cortex_development 0.7
Publications: 1 Organism: Homo Sapiens