Relation Results

Summary

Name PTGER2
Full Name Prostaglandin E2 receptor EP2 subtype
Synonyms PGE receptor EP2 subtype, PGE2 receptor EP2 subtype, Prostanoid EP2 receptor
Primary ID P43116
Links - -
Type protein
Relations 6
Pathways GPCR_CRC
Function Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent rais ...
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Type: Score: Layout: SPV 
0.80.80.250.2960.43prostaglandin E2PTGER2prostaglandin E2(1-)GNALEGFRGNAS

Relations

Regulator
Mechanism
target
score
+ up-regulates img/direct-activation.png chemical activation PTGER2 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-127735 Homo sapiens
pmid sentence
Pge2 acts via four ep receptors termed ep1 to ep4.
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation PTGER2 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-257570 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAL 0.25
Identifier Residue Sequence Organism Cell Line
SIGNOR-256899 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png EGFR 0.296
Identifier Residue Sequence Organism Cell Line
SIGNOR-152805 Homo sapiens Colonic Cancer Cell
pmid sentence
Ep2 can also promote the transactivation of epidermal growth factor receptor (egfr) expressed in colon cancer cells through src, which activates the proteolytic release of the egfr ligands amphiregulin (ar) and transforming growth factor-alfa (tgfalfa).
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAS 0.43
Identifier Residue Sequence Organism Cell Line
SIGNOR-256756 Homo sapiens
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ‚â• -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ‚â• -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ‚â• -1.0.
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNAS 0.43
Identifier Residue Sequence Organism Cell Line
SIGNOR-141597 Homo sapiens
pmid sentence
Pge2 receptors are coupled to the g protein gs, which causes accumulation of cyclic adenosine monophosphate (camp) and activates protein kinase a (pka), we confirmed that pge2 treatment or transfection of cells with the active catalytic subunit of pka also stimulated the activity of a camp-responsive-elementdriven reporter gene (cre-luc).
Publications: 1 Organism: Homo Sapiens
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