| + |
GRK6 | down-regulates quantity by destabilization 
phosphorylation
|
IGF1R |
0.311 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276412 |
Ser1321 |
LPLPDRHsGHKAENG |
in vitro |
|
| pmid |
sentence |
| 22509025 |
GRK2 and GRK6 coimmunoprecipitate with IGF-1R and increase IGF-1R serine phosphorylation, promoting β-arrestin1 association. Using immunoprecipitation, confocal microscopy, and FRET analysis, we demonstrated β-arrestin/IGF-1R association to be transient for GRK2 and stable for GRK6. Using bioinformatic studies we identified serines 1248 and 1291 as the major serine phosphorylation sites of the IGF-1R. Targeted mutation of S1248 recapitulates GRK2 modulation, whereas S1291 mutation resembles GRK6 effects on IGF-1R signaling/degradation |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
GRK6 | down-regulates activity
phosphorylation
|
SLC9A3R1 |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251214 |
Ser290 |
PALVRSAsSDTSEEL |
Homo sapiens |
|
| pmid |
sentence |
| 10446210 |
GRK6A phosphorylates NHERF on Ser289, the primary site of constitutive phosphorylation of NHERF in HEK-293 cells. The interaction of NHERF and NHE3 is mediated by the region of NHERF encompassing the second PDZ domain and the tail (25), and it is therefore reasonable that phosphorylation of the serine-rich stretch in the center of this region (including Ser289) might affect the physical interaction of NHERF with NHE3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRK6 | down-regulates activity
phosphorylation
|
BDKRB2 |
0.292 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251207 |
Ser366 |
EPIQMENsMGTLRTS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11517230 |
Ligand-induced phosphorylation is found at Ser339 and Ser346/Ser348 that could be executed by several G protein-coupled receptor kinases. 32P labeling of peptide 3 containing pS346/pS348 was enhanced 1.5–3-fold as compared with mock-transfected cells in the order GRK6 < GRK5 < GRK2 < GRK4α < GRK3. several endogenous GRKs may phosphorylate the B2R and that the various GRKs, even without apparent effect on total GPCR phosphorylation levels, may induce distinct phosphorylation patterns with possible functional consequences for receptor desensitization and sequestration. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251205 |
Ser373 |
SMGTLRTsISVERQI |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11517230 |
Ligand-induced phosphorylation is found at Ser339 and Ser346/Ser348 that could be executed by several G protein-coupled receptor kinases. 32P labeling of peptide 3 containing pS346/pS348 was enhanced 1.5–3-fold as compared with mock-transfected cells in the order GRK6 < GRK5 < GRK2 < GRK4α < GRK3. several endogenous GRKs may phosphorylate the B2R and that the various GRKs, even without apparent effect on total GPCR phosphorylation levels, may induce distinct phosphorylation patterns with possible functional consequences for receptor desensitization and sequestration. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251206 |
Ser375 |
GTLRTSIsVERQIHK |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11517230 |
Ligand-induced phosphorylation is found at Ser339 and Ser346/Ser348 that could be executed by several G protein-coupled receptor kinases. 32P labeling of peptide 3 containing pS346/pS348 was enhanced 1.5–3-fold as compared with mock-transfected cells in the order GRK6 < GRK5 < GRK2 < GRK4α < GRK3. several endogenous GRKs may phosphorylate the B2R and that the various GRKs, even without apparent effect on total GPCR phosphorylation levels, may induce distinct phosphorylation patterns with possible functional consequences for receptor desensitization and sequestration. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
GRK6 |
phosphorylation
|
GRK6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251211 |
Ser484 |
VLDIEQFsTVKGVEL |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10334944 |
GRK6 Is Autophosphorylated in COS-7 Cells. GRK6, like GRK5, is autophosphorylated on Ser484 and Thr485. Whether the autophosphorylation of GRK6 modulates its activity remains however to be established. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251212 |
Thr485 |
LDIEQFStVKGVELE |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10334944 |
GRK6 Is Autophosphorylated in COS-7 Cells. GRK6, like GRK5, is autophosphorylated on Ser484 and Thr485. Whether the autophosphorylation of GRK6 modulates its activity remains however to be established. |
|
| Publications: |
2 |
Organism: |
Chlorocebus Aethiops |
| + |
GRK6 | down-regulates activity
phosphorylation
|
LTB4R |
0.487 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251213 |
Thr308 |
VAKLLEGtGSEASST |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 12077128 |
Thr(308) is a major residue involved in GRK6-mediated desensitization of BLT1 signaling. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
GRK6 | down-regulates activity
phosphorylation
|
MC1R |
0.319 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252389 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15650023 |
Overexpression of GRK6 Inhibits Agonist-Induced cAMP Production in HBL Human Melanoma Cells, without Affecting MC1R Gene Expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GRK6
- 
- 