| + |
CXCL2 | up-regulates activity 
binding
|
CXCR2 |
0.73 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277718 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 38309677 |
CXCL2/3, also known as macrophage inflammatory protein-2α/2β (MIP-2α/MIP-2β), share the same receptor CXCR2 with CXCL1 and are able to activate neutrophils effectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CXCL1 | up-regulates activity
binding
|
CXCR2 |
0.769 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277717 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 38309677 |
CXCL1 produces cellular chemotactic activity by binding to the CXC chemokine receptor 2 (CXCR2). In PC, this chemokine has been associated with a variety of carcinogenic mechanisms, including oncogene-induced senescence (OIS), angiogenesis, cancer metastasis, and immunosuppressive microenvironments |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CXCL3 | up-regulates activity
binding
|
CXCR2 |
0.713 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277719 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 38309677 |
CXCL2/3, also known as macrophage inflammatory protein-2α/2β (MIP-2α/MIP-2β), share the same receptor CXCR2 with CXCL1 and are able to activate neutrophils effectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CXCL5 | up-regulates activity
binding
|
CXCR2 |
0.744 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277730 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 38339310 |
CXCL5 is another ELR+ CXC chemokine and, thus, also potently attracts neutrophils. Just like CXCL1, CXCL5 also signals through CXCR2, explaining why, often, CXCL5 and CXCL1 are seen to function in parallel in PDAC. CXCL5 was increased in human pancreatic tissue compared to the normal pancreas, and the knockdown of CXCL5 in pancreatic cancer cell lines reduced the proliferation and migration ability of cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARG | up-regulates quantity by expression
transcriptional regulation
|
CXCR2 |
0.267 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271682 |
|
|
|
|
| pmid |
sentence |
| 18292390 |
EMSA, ChIP, and transient transfection assays indicate that PPAR-gamma activates the CXCR2 promoter by binding to a PPAR response element (PPRE). |
|
| Publications: |
1 |
| + |
CXCL8 | up-regulates
binding
|
CXCR2 |
0.856 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107983 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11350788 |
Il-8 activates both the cxcr1 and the cxcr2 on microvascular endothelial cells, using different signal transduction cascades. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRK2 | down-regulates activity 
phosphorylation
|
CXCR2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260647 |
|
|
Mus musculus |
Lung |
| pmid |
sentence |
| 22634615 |
Upon activation, GRK2 phosphorylates CXCR2 and causes receptor desensitization and internalization, leading to down-regulation of neutrophil chemotaxis |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MIF | up-regulates activity
binding
|
CXCR2 |
0.392 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252061 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17435771 |
We identify the chemokine receptors CXCR2 and CXCR4 as functional receptors for MIF [] By activating both CXCR2 and CXCR4, MIF displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Toll like receptors |
3.0
CXCR2
- 
- 