Summary

Name NKX2-1
Full Name Homeobox protein Nkx-2.1
Synonyms Homeobox protein NK-2 homolog A, Thyroid nuclear factor 1, Thyroid transcription factor 1, TTF-1, Thyroid-specific enhancer-binding protein, T/EBP | NKX2A, TITF1, TTF1
Primary ID P43699
Links - -
Type protein
Relations 4
Pathways Thyroid Hormone Metabolism
Function Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity).

Viewer

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png binding NKX2-1 0.297
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TPO 0.393
Publications: 1 Organism: Homo Sapiens
Tissue: Hypophysis
Pathways:Thyroid Hormone Metabolism
+ up-regulates img/direct-activation.png binding NKX2-1 0.437
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:Thyroid Hormone Metabolism
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SFTPB 0.493
Publications: 1 Organism: Homo Sapiens