| + |
CSNK1E | down-regulates 
phosphorylation
|
WWTR1 |
0.337 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230747 |
Ser314 |
SREQSTDsGLGLGCY |
Homo sapiens |
|
| pmid |
sentence |
| 24715453 |
LATS1/2-mediated phosphorylation of a conserved serine in this region (Ser311 in human TAZ; Ser397 in human YAP) primes for further phosphorylation by CK1_/_ kinases (Ser314 on human TAZ; Ser400/403 in human YAP) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
CSNK1D | down-regulates
phosphorylation
|
WWTR1 |
0.337 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-234438 |
Ser314 |
SREQSTDsGLGLGCY |
Homo sapiens |
|
| pmid |
sentence |
| 24715453 |
LATS1/2-mediated phosphorylation of a conserved serine in this region (Ser311 in human TAZ; Ser397 in human YAP) primes for further phosphorylation by CK1_/_ kinases (Ser314 on human TAZ; Ser400/403 in human YAP) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
LATS1/2 | down-regulates activity
phosphorylation
|
WWTR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256187 |
Ser89 |
AQHVRSHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 22658639 |
In response to high cell densities, activated LATS1/2 phosphorylates the WW-domain containing transcriptional co-activators YAP at Ser127 and TAZ at Ser89, promoting 14-3-3 binding and thereby inhibiting their translocation into the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo in cancer, Hippo Signaling, Integrin Signaling |
| + |
LATS2 | down-regulates
phosphorylation
|
WWTR1 |
0.685 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197651 |
Ser89 |
AQHVRSHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 22658639 |
In response to high cell densities, activated LATS1/2 phosphorylates the WW-domain containing transcriptional co-activators YAP at Ser127 and TAZ at Ser89, promoting 14-3-3 binding and thereby inhibiting their translocation into the nucleus. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175787 |
Ser89 |
AQHVRSHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Activated lats1/2 in turn phosphorylate and inhibit yap/taz transcription co-activators |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
LATS1 | down-regulates
phosphorylation
|
WWTR1 |
0.783 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175783 |
Ser89 |
AQHVRSHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Activated lats1/2 in turn phosphorylate and inhibit yap/taz transcription co-activators. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197643 |
Ser89 |
AQHVRSHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 22658639 |
In response to high cell densities, activated LATS1/2 phosphorylates the WW-domain containing transcriptional co-activators YAP at Ser127 and TAZ at Ser89, promoting 14-3-3 binding and thereby inhibiting their translocation into the nucleus. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
WWTR1 | up-regulates 
binding
|
PAX3 |
0.468 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236879 |
|
|
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 16300735 |
These results indicate that pax3 specifically interacts with taz both in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
WWTR1 | up-regulates
binding
|
TEAD4 |
0.863 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201459 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
When dephosphorylated, yap/taz enter nuclei and induce gene transcription by interacting with transcription factors tead14. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
14-3-3 | down-regulates
binding
|
WWTR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169716 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Phosphorylation of yap ser127 and of the corresponding sites in yki and taz generates a protein-binding motif for the 14-3-3 family proteins, which, upon binding by a 14-3-3 protein, leads to their cytoplasmic retention. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
METTL3 | up-regulates quantity by expression
transcriptional regulation
|
WWTR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265955 |
|
|
Homo sapiens |
HEK-293 Cell, HeLa Cell |
| pmid |
sentence |
| 27117702 |
Here we find that METTL3 promotes translation of certain mRNAs including epidermal growth factor receptor (EGFR) and the Hippo pathway effector TAZ in human cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWTR1 | up-regulates quantity by expression 
transcriptional regulation
|
LTBR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255604 |
|
|
Homo sapiens |
Colorectal Cancer Cell |
| pmid |
sentence |
| 22470139 |
Efficient knockdown of WWTR1, demonstrated by quantitative real-time PCR, led to upregulation of ASNS and downregulation of SMAD3, LTBR, BAX and BAK1 in WWTR1 knockdown cells, suggesting that these genes may be involved in the repression of cell proliferation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWTR1 | down-regulates
binding
|
DVL1 |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195212 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22153608 |
Taz binds to dvl proteins, thereby inhibiting dvl phosphorylation by casein kinase 1-delta and -epsilon kinases (ck1d/e), thus promoting beta-catenin degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWTR1 | up-regulates
binding
|
TEAD1 |
0.86 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-192768 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
When dephosphorylated, yap/taz enter nuclei and induce gene transcription by interacting with transcription factors tead1?_?_?4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWTR1 | up-regulates
binding
|
SMAD2 |
0.573 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169835 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Taz has been shown to interact with smad2 and smad3 through its coiled-coil region, and to be important in maintaining the nuclear localization of smad2 and smad3 as well as the expression of their target genes in response to tgf-b signaling and, thus, in the maintenance of human esc self-renewal. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCF-betaTRCP | down-regulates quantity by destabilization
ubiquitination
|
WWTR1 |
0.417 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230750 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Phosphorylation of YAP (S381) and TAZ (S311) by Lats1/2 primes subsequent phosphorylation events by casein kinase 1 (CK1d/e); this sequential phosphorylation results in recruitment of b-transducin repeat-containing proteins (b-TRCP; a subunit of the SCF ubiquitin E3 ligase) and consequently leads to degradation of YAP/TAZ |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
AMOT | down-regulates
relocalization
|
WWTR1 |
0.668 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201132 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Yap/taz and angiomotin (amot) family proteins were shown to interact, resulting in yap/taz localization to tight junctions and inhibition through phosphorylation-dependent and -independent mechanisms. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175776 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21205866 |
Our results indicate a potential tumor-suppressing role of AMOT family proteins as components of the Hippo pathway, and demonstrate a novel mechanism of YAP and TAZ inhibition by AMOT-mediated tight junction localization. These observations provide a potential link between the Hippo pathway and cell contact inhibition. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
WWTR1 | up-regulates
binding
|
RUNX2 |
0.527 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195218 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22153608 |
Taz binding to the transcription factor runx2 promotes osteoblast lineage specification, whereas taz binding to the transcription factor ppargamma inhibits adipogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWTR1 | up-regulates quantity by expression
transcriptional regulation
|
BAX |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255606 |
|
|
Homo sapiens |
Colorectal Cancer Cell |
| pmid |
sentence |
| 22470139 |
Efficient knockdown of WWTR1, demonstrated by quantitative real-time PCR, led to upregulation of ASNS and downregulation of SMAD3, LTBR, BAX and BAK1 in WWTR1 knockdown cells, suggesting that these genes may be involved in the repression of cell proliferation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TJP2 | down-regulates
binding
|
WWTR1 |
0.48 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175931 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
In addition, yap and taz interact with another tight junction protein zo-2, which was reported to increase nuclear localization of yap and tight-junction localization of taz. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
WWTR1 | up-regulates activity
binding
|
SMAD2 |
0.573 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169838 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Taz has been shown to interact with smad2 and smad3 through its coiled-coil region, and to be important in maintaining the nuclear localization of smad2 and smad3 as well as the expression of their target genes in response to tgf-b signaling and, thus, in the maintenance of human esc self-renewal. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWTR1 | up-regulates
binding
|
TTF1 |
0.318 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182296 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19010321 |
Taz is a coactivator for pax8 and ttf-1, two transcription factors involved in thyroid differentiation. / we show that this interaction leads to a significant enhancement of the transcriptional activity of pax8 and ttf-1 on the thyroglobulin promoter thus suggesting a role of taz in the control of genes involved in thyroid development and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Lung |
| + |
WWTR1 | up-regulates
binding
|
PAX8 |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182253 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19010321 |
Taz is a coactivator for pax8 and ttf-1, two transcription factors involved in thyroid differentiation. / we show that this interaction leads to a significant enhancement of the transcriptional activity of pax8 and ttf-1 on the thyroglobulin promoter thus suggesting a role of taz in the control of genes involved in thyroid development and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Lung |
| Pathways: | Thyroid Hormone Metabolism |
| + |
WWTR1 | down-regulates
binding
|
PPARG |
0.319 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195215 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22153608 |
Kmp also enhanced the association of taz with ppar_, thereby suppressing the gene transcription of ppar_ targets and resulting in diminished adipocyte differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWTR1 | up-regulates
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199211 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23075495 |
Yap and taz are two main downstream effectors of the hippo pathway, and they function as transcription co-activators to promote cell proliferation and inhibit apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo in cancer, Hippo Signaling, Integrin Signaling |
| + |
WWTR1 | down-regulates quantity by repression 
transcriptional regulation
|
ASNS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255608 |
|
|
Homo sapiens |
Colorectal Cancer Cell |
| pmid |
sentence |
| 22470139 |
Efficient knockdown of WWTR1, demonstrated by quantitative real-time PCR, led to upregulation of ASNS and downregulation of SMAD3, LTBR, BAX and BAK1 in WWTR1 knockdown cells, suggesting that these genes may be involved in the repression of cell proliferation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWTR1 | up-regulates activity
binding
|
SMAD3 |
0.532 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-232098 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Taz has been shown to interact with smad2 and smad3 through its coiled-coil region, and to be important in maintaining the nuclear localization of smad2 and smad3 as well as the expression of their target genes in response to tgf-b signaling and, thus, in the maintenance of human esc self-renewal. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
TEAD | up-regulates activity
binding
|
WWTR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230722 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
YAP/TAZ do not contain intrinsic DNA-binding domains but instead bind to the promoters of target genes by interacting with DNA-binding transcription factors. YAP/TAZ mainly bind to the transcription factors TEAD1–4 to regulate genes involved in cell proliferation and cell death |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo in cancer, Hippo Signaling, Integrin Signaling |
| + |
WWTR1 | up-regulates
binding
|
NKX2-1 |
0.437 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143472 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16397409 |
Taz also binds to the transcription factor ttf-1 that is involved in formation and differentiation of the lungs and respiratory epithelia, and stimulates the production of pulmonary surfactant. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| Pathways: | Thyroid Hormone Metabolism |
| + |
WWTR1 | down-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256668 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23075495 |
Yap and taz are two main downstream effectors of the hippo pathway, and they function as transcription co-activators to promote cell proliferation and inhibit apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWTR1 | down-regulates
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199208 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23075495 |
Yap and taz are two main downstream effectors of the hippo pathway, and they function as transcription co-activators to promote cell proliferation and inhibit apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo in cancer, Hippo Signaling, Integrin Signaling |
| + |
WWTR1 | up-regulates quantity by expression
transcriptional regulation
|
BAK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255605 |
|
|
Homo sapiens |
Colorectal Cancer Cell |
| pmid |
sentence |
| 22470139 |
Efficient knockdown of WWTR1, demonstrated by quantitative real-time PCR, led to upregulation of ASNS and downregulation of SMAD3, LTBR, BAX and BAK1 in WWTR1 knockdown cells, suggesting that these genes may be involved in the repression of cell proliferation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMOT/MPP5/INADL/LIN7C | down-regulates
binding
|
WWTR1 |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170361 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21145499 |
Because we found that multiple domains of taz/yap interacted with multiple components of the crumbs complex, which include pals1, lin7c, patj, and the crumbs regulator amot, we propose that this multifactoral interaction serves to ensure that assembly of the hippo pathway and efficient phosphorylation of taz/yap is coupled only by the assembly of the crumbs complex, rather than by any single component. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Hippo Signaling |
| + |
WWTR1 | up-regulates
binding
|
TEAD3 |
0.684 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201415 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
When dephosphorylated, yap/taz enter nuclei and induce gene transcription by interacting with transcription factors tead14. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWTR1 | up-regulates quantity by expression
transcriptional regulation
|
SMAD3 |
0.532 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255607 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22470139 |
Efficient knockdown of WWTR1, demonstrated by quantitative real-time PCR, led to upregulation of ASNS and downregulation of SMAD3, LTBR, BAX and BAK1 in WWTR1 knockdown cells, suggesting that these genes may be involved in the repression of cell proliferation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
WWTR1 | up-regulates
binding
|
TEAD2 |
0.797 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201382 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
When dephosphorylated, yap/taz enter nuclei and induce gene transcription by interacting with transcription factors tead14. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWTR1 | up-regulates
binding
|
SMAD3 |
0.532 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169841 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Taz has been shown to interact with smad2 and smad3 through its coiled-coil region, and to be important in maintaining the nuclear localization of smad2 and smad3 as well as the expression of their target genes in response to tgf-b signaling and, thus, in the maintenance of human esc self-renewal. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
WWTR1 | up-regulates
binding
|
MYOD1 |
0.282 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165414 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20466877 |
Taz physically interacts with myod through the ww domain and activates myod-dependent gene transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
WWTR1
- 
- 