Summary

Name ALDH1A3
Full Name Aldehyde dehydrogenase family 1 member A3
Synonyms Aldehyde dehydrogenase 6, Retinaldehyde dehydrogenase 3, RALDH-3, RalDH3 | ALDH6
Primary ID P47895
Links - -
Type protein
Relations 2
Pathways Retinoic Acid Metabolism
Function NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid (PubMed:27759097). Has high activity with all-trans retinal, and has much lower in vitro activity with acetaldehyde (PubMed:27759097). Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions; retinoic acid is required for normal embryonic development of the eye and the nasal region (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ ALDH1A3down-regulates quantity img/direct_inhibition.png chemical modification retinal 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Retinoic Acid Metabolism
+ ALDH1A3up-regulates quantity img/direct-activation.png chemical modification all-trans-retinoic acid 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Retinoic Acid Metabolism