3.0
Summary
| Name |  CD44View Modifications |
| Full Name | CD44 antigen |
| Synonyms | CDw44, Epican, Extracellular matrix receptor III, ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, PGP-1, Phagocytic glycoprotein I, PGP-I | LHR, MDU2, MDU3, MIC4 |
| Primary ID | P16070 |
| Links |  -  -  |
| Type | protein |
| Relations | 12 |
| Function | Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKACA | up-regulates 
phosphorylation
|
CD44 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CAMK2A | up-regulates
phosphorylation
|
CD44 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CAMK2A | up-regulates activity
phosphorylation
|
CD44 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NUP98-HOXA9 | up-regulates quantity by expression 
transcriptional regulation
|
CD44 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TWIST2 | up-regulates quantity by expression
transcriptional regulation
|
CD44 | 0.455 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SNAI2 | up-regulates quantity by expression
transcriptional regulation
|
CD44 | 0.419 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | F2R | up-regulates quantity by expression
transcriptional regulation
|
CD44 | 0.252 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TWIST1 | up-regulates quantity by expression
transcriptional regulation
|
CD44 | 0.53 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | F2RL1 | up-regulates quantity by expression
transcriptional regulation
|
CD44 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NOTCH1 | up-regulates quantity by expression
transcriptional regulation
|
CD44 | 0.428 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ZMYND8 | down-regulates quantity by repression 
transcriptional regulation
|
CD44 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ADAM10 | up-regulates activity
cleavage
|
CD44 | 0.354 |
| Publications: | 1 | Organism: | Homo Sapiens | |