Relation Results

Summary

Name CD44
Full Name CD44 antigen
Synonyms CDw44, Epican, Extracellular matrix receptor III, ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, PGP-1, Phagocytic glycoprotein I, PGP-I | LHR, MDU2, MDU3, MIC4
Primary ID P16070
Links - -
Type protein
Relations 12
Function Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the ti ...
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Type: Score: Layout: SPV 
0.20.20.4540.20.20.3520.5290.2520.4250.20.417PRKACACD44CAMK2ATWIST2F2RL1ZMYND8ADAM10TWIST1F2RNOTCH1NUP98-HOXA9SNAI2

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PRKACAup-regulates img/direct-activation.png phosphorylation CD44 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-147208 Ser697 AVEDRKPsGLNGEAS Homo sapiens
pmid sentence
Pka can phosphorylate ser316 directly cd44 s291a and s316a mutants may disrupt downstream signalling events by displacing endogenous cd44 from plasma membrane microdomains.
Publications: 1 Organism: Homo Sapiens
+ CAMK2Aup-regulates img/direct-activation.png phosphorylation CD44 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-57376 Ser706 LNGEASKsQEMVHLV Homo sapiens
pmid sentence
We demonstrate here that cd44 is phosphorylated to high stoichiometry in resting cells and that ca(2+)/calmodulin-dependent protein kinase ii is a cd44 ser(325) kinase.
Publications: 1 Organism: Homo Sapiens
+ CAMK2Aup-regulates activity img/direct-activation.png phosphorylation CD44 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-109502 Ser706 LNGEASKsQEMVHLV Homo sapiens Fibroblast
pmid sentence
In previous studies we have demonstrated that a key control point for this receptor is the phosphorylation of CD44 on a conserved cytoplasmic serine residue, Ser(325). This modification is not required for efficient ligand binding, but is an essential component of CD44-dependent cell migration on a hyaluronan substratum. We demonstrate here that cd44 is phosphorylated to high stoichiometry in resting cells and that ca(2+)/calmodulin-dependent protein kinase ii is a cd44 ser(325) kinase.
Publications: 1 Organism: Homo Sapiens
+ TWIST2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD44 0.454
Identifier Residue Sequence Organism Cell Line
SIGNOR-255517 Homo sapiens HEY Cell
pmid sentence
Immunoblot analysis showed that HEY/si-TWIST cells exhibited decreased expression levels of CD29, CD44 and CD54 compared to those of HEY/si-scrambled cells
Publications: 1 Organism: Homo Sapiens
+ F2RL1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD44 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254843 Homo sapiens
pmid sentence
Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4) known to be important in cancer.
Publications: 1 Organism: Homo Sapiens
+ ZMYND8down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CD44 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-262039 Homo sapiens Prostate Cancer Cell Line
pmid sentence
Our quantitative ChIP experiments confirmed that ZMYND8 and JARID1D were co-localized at Slug, CD44, VEGFA, and EGFR genes (Figures 4F–4I). Our ChIP results also showed that ZMYND8 repressed and occupied other JARID1D target genes, such as the matrix metalloproteinase 1 (MMP1) and MMP3, that we previously reported
Publications: 1 Organism: Homo Sapiens
+ ADAM10up-regulates activity img/direct-activation.png cleavage CD44 0.352
Identifier Residue Sequence Organism Cell Line
SIGNOR-259847 Homo sapiens
pmid sentence
The ADAM proteases are best known for their role in shedding the extracellular domain of transmembrane proteins. Among the transmembrane proteins shed by ADAM10 are notch, HER2, E-cadherin, CD44, L1 and the EGFR ligands, EGF and betacellulin.
Publications: 1 Organism: Homo Sapiens
+ TWIST1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD44 0.529
Identifier Residue Sequence Organism Cell Line
SIGNOR-255512 Homo sapiens HEY Cell
pmid sentence
Immunoblot analysis showed that HEY/si-TWIST cells exhibited decreased expression levels of CD29, CD44 and CD54 compared to those of HEY/si-scrambled cells
Publications: 1 Organism: Homo Sapiens
+ F2Rup-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD44 0.252
Identifier Residue Sequence Organism Cell Line
SIGNOR-254851 Homo sapiens
pmid sentence
Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4) known to be important in cancer.
Publications: 1 Organism: Homo Sapiens
+ NOTCH1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD44 0.425
Identifier Residue Sequence Organism Cell Line
SIGNOR-80333 Homo sapiens Thymoma Cell
pmid sentence
Activation of notch1 signaling in dp thymocytes and thymoma cell lines results in the upregulation of cd25 and cd44 expression
Publications: 1 Organism: Homo Sapiens
+ NUP98-HOXA9up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD44 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-261502 Homo sapiens
pmid sentence
Over 102 cytoplasmic mRNAs were significantly altered in K562 myeloid leukemic cells transduced with NUP98‐HOXA9, 92 being increased and only 10 decreased. CD44 is also upregulated by NUP98‐HOXA9.
Publications: 1 Organism: Homo Sapiens
+ SNAI2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD44 0.417
Identifier Residue Sequence Organism Cell Line
SIGNOR-255153 Homo sapiens Breast Cancer Cell
pmid sentence
SLUG up-regulation engenders breast cancer cells with stem cell-like properties including enhanced expression of CD44 and Jagged-1 in conjunction with estrogen receptor alpha down-regulation, growth as mammospheres, and extracellular matrix invasiveness.
Publications: 1 Organism: Homo Sapiens
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