| + |
MMP3 | up-regulates activity 
cleavage
|
SPP1 |
0.666 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253320 |
|
|
|
|
| pmid |
sentence |
| 25545242 |
In this study, we found a novel motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved mouse OPN binds to α9β1 integrin. Importantly, this novel motif is involved in the development of anti-type II collagen antibody-induced arthritis (CAIA). This study provides the first in vitro and in vivo evidence that OPN cleavage by MMP-3/7 is an important regulatory mechanism for CAIA. |
|
| Publications: |
1 |
| + |
FAM20C | down-regulates quantity 
phosphorylation
|
SPP1 |
0.681 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278936 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34433585 |
OPN phosphorylation by Fam20C decreased OPN secretion, and OPN neutralization reduced Fam20C-deficiency-induced osteoclast differentiation and bone metastasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPP1 | up-regulates activity
binding
|
A9/b1 integrin |
0.616 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253311 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24241034 |
Synovial fibroblasts and macrophages derived from arthritic joints spontaneously secreted tenascin-C and osteopontin. Synovial fibroblasts and macrophages obtained from patients with RA expressed α9β1 integrins, a common receptor for osteopontin and tenascin-C. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPP1 | up-regulates
binding
|
Av/b3 integrin |
0.618 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77910 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10835423 |
Among others, vitronectin (vn)1- (11, 13, 14) and osteopontin (opn)-coated (15-20) substrates have been shown to support cell adhesion via avb3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | up-regulates quantity by expression 
transcriptional regulation
|
SPP1 |
0.508 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107175 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11331591 |
In addition to osteocalcin, cbfa1 regulates expression of several other genes that are activated during osteoblast |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERG | up-regulates quantity by expression
transcriptional regulation
|
SPP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254066 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21669963 |
Using in vitro and in vivo molecular assays, we showed that ERG increases OPN expression and binds to an EBS (nt -115 to -118) in the OPN promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DLX5 | up-regulates quantity
transcriptional regulation
|
SPP1 |
0.384 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-245340 |
|
|
Gallus gallus |
|
| pmid |
sentence |
| 17335796 |
Dlx5 initiates a complete osteogenic differentiation in these early primary cells, by triggering Runx2, osteopontin, alkaline phosphatase, and other gene expression according to the sequential temporal sequence observed during skull osteogenesis in vivo. |
|
| Publications: |
1 |
Organism: |
Gallus Gallus |
| + |
ALPL | down-regulates activity
dephosphorylation
|
SPP1 |
0.458 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277045 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23427088 |
This result suggests that endogenous mouse TNAP dephosphorylates OPN in osteoblasts and that overexpressed human TNAP dephosphorylates OPN, compensating for the lack of endogenous TNAP in [Col1a1-Tnap +/\u2212 ;Alpl \u2212/\u2212 ] cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ETS2 | up-regulates quantity by expression
transcriptional regulation
|
SPP1 |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259872 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11175361 |
We demonstrated that Ets2 is capable of binding to and transactivating the OPN promoter using gel shift and transient transfection assays |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MMP7 | up-regulates activity
cleavage
|
SPP1 |
0.704 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253321 |
|
|
|
|
| pmid |
sentence |
| 25545242 |
In this study, we found a novel motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved mouse OPN binds to α9β1 integrin. Importantly, this novel motif is involved in the development of anti-type II collagen antibody-induced arthritis (CAIA). This study provides the first in vitro and in vivo evidence that OPN cleavage by MMP-3/7 is an important regulatory mechanism for CAIA. |
|
| Publications: |
1 |
| + |
RUNX2 | up-regulates quantity
transcriptional regulation
|
SPP1 |
0.508 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-245336 |
|
|
Mus musculus |
Colorectal Cancer Cell Line |
| pmid |
sentence |
| 16670084 |
Ets-1 and Runx2 are critical transcriptional regulators of OPN expression in CT26 colorectal cancer cells. Suppression of these transcription factors results in significant down-regulation of the OPN metastasis protein. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMOC1 | up-regulates quantity by expression
transcriptional regulation
|
SPP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260385 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20359165 |
The expression of several osteoblast differentiation markers (ALP, COL1, OPN, ON, BSP and OC) was higher in SMOC1-overexpressing cells than in emptyvector-expressing cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
SPP1
- 
- 