| + |
SPP1 | up-regulates activity 
binding
|
ITGB3 |
0.598 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282536 |
|
|
Homo sapiens |
Mesenchymal Cell, Pancreatic Ductal Carcinoma Cell |
| pmid |
sentence |
| 40993391 |
SPP1 bound the CD61 receptor on mesenchymal PDAC cells to induce Bmp2 and Grem1 expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPP1 | up-regulates quantity by expression 
transcriptional regulation
|
BMI1 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282551 |
|
|
Homo sapiens |
Fibroblast, Pancreatic Ductal Carcinoma Cell |
| pmid |
sentence |
| 34418441 |
The OPN/SPP1 KD CAF-CM treated cells significantly reduced the OPN/SPP1, ALDH1A1, ALDH1A3, CD44, KLF4, SOX2, OCT3/4, SOX9, BMI1, and NANOG |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERG | up-regulates quantity by expression
transcriptional regulation
|
SPP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254066 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21669963 |
Using in vitro and in vivo molecular assays, we showed that ERG increases OPN expression and binds to an EBS (nt -115 to -118) in the OPN promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FAM20C | down-regulates quantity 
phosphorylation
|
SPP1 |
0.698 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278936 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34433585 |
OPN phosphorylation by Fam20C decreased OPN secretion, and OPN neutralization reduced Fam20C-deficiency-induced osteoclast differentiation and bone metastasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPP1 | up-regulates quantity by expression
transcriptional regulation
|
KLF4 |
0.312 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282542 |
|
|
Homo sapiens |
Fibroblast, Pancreatic Ductal Carcinoma Cell |
| pmid |
sentence |
| 34418441 |
OPN/SPP1 KD decreased the expressions of KLF4, NANOG, OCT3/4, and ABCG2 compared to scrambled control CAF-CM-treated PC cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | up-regulates quantity
transcriptional regulation
|
SPP1 |
0.483 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-245336 |
|
|
Mus musculus |
Colorectal Cancer Cell Line |
| pmid |
sentence |
| 16670084 |
Ets-1 and Runx2 are critical transcriptional regulators of OPN expression in CT26 colorectal cancer cells. Suppression of these transcription factors results in significant down-regulation of the OPN metastasis protein. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SPP1 | up-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282540 |
|
|
Homo sapiens |
Pancreatic Ductal Carcinoma Cell |
| pmid |
sentence |
| 40993391 |
Epithelial PDAC cells secrete SPP1 to maintain mesenchymal PDAC cells. Immunofluorescence staining of KPCY tumours revealed that SPP1 was predominantly expressed in epithelial PDAC cells (EPCs) and not in vimentin (VIM)-positive mesenchymal PDAC cells (MPCs) (Fig. 1d). Spp1 overexpression induces mesenchymal transition of PDAC. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPP1 | up-regulates activity
binding
|
CD44 |
0.778 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282541 |
|
|
Homo sapiens |
Fibroblast, Pancreatic Ductal Carcinoma Cell |
| pmid |
sentence |
| 34418441 |
OPN/SPP1 interacts with CD44 to induce cell signaling that modulates cell adhesion, movement, and activation of neoplastic cells leading to tumor progression and metastases |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPP1 | up-regulates quantity by expression
transcriptional regulation
|
NANOG |
0.33 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282543 |
|
|
Homo sapiens |
Fibroblast, Pancreatic Ductal Carcinoma Cell |
| pmid |
sentence |
| 34418441 |
OPN/SPP1 KD decreased the expressions of KLF4, NANOG, OCT3/4, and ABCG2 compared to scrambled control CAF-CM-treated PC cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPP1 | up-regulates quantity by expression
transcriptional regulation
|
POU5F1 |
0.395 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282544 |
|
|
Homo sapiens |
Fibroblast, Pancreatic Ductal Carcinoma Cell |
| pmid |
sentence |
| 34418441 |
OPN/SPP1 KD decreased the expressions of KLF4, NANOG, OCT3/4, and ABCG2 compared to scrambled control CAF-CM-treated PC cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPP1 | up-regulates quantity by expression
transcriptional regulation
|
ABCG2 |
0.369 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282545 |
|
|
Homo sapiens |
Fibroblast, Pancreatic Ductal Carcinoma Cell |
| pmid |
sentence |
| 34418441 |
OPN/SPP1 KD decreased the expressions of KLF4, NANOG, OCT3/4, and ABCG2 compared to scrambled control CAF-CM-treated PC cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPP1 | up-regulates quantity by expression
transcriptional regulation
|
CD44 |
0.778 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282546 |
|
|
Homo sapiens |
Fibroblast, Pancreatic Ductal Carcinoma Cell |
| pmid |
sentence |
| 34418441 |
The OPN/SPP1 KD CAF-CM treated cells significantly reduced the OPN/SPP1, ALDH1A1, ALDH1A3, CD44, KLF4, SOX2, OCT3/4, SOX9, BMI1, and NANOG |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPP1 | up-regulates quantity by expression
transcriptional regulation
|
ALDH1A1 |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282547 |
|
|
Homo sapiens |
Fibroblast, Pancreatic Ductal Carcinoma Cell |
| pmid |
sentence |
| 34418441 |
The OPN/SPP1 KD CAF-CM treated cells significantly reduced the OPN/SPP1, ALDH1A1, ALDH1A3, CD44, KLF4, SOX2, OCT3/4, SOX9, BMI1, and NANOG |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPP1 | up-regulates quantity by expression
transcriptional regulation
|
ALDH1A3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282548 |
|
|
Homo sapiens |
Fibroblast, Pancreatic Ductal Carcinoma Cell |
| pmid |
sentence |
| 34418441 |
The OPN/SPP1 KD CAF-CM treated cells significantly reduced the OPN/SPP1, ALDH1A1, ALDH1A3, CD44, KLF4, SOX2, OCT3/4, SOX9, BMI1, and NANOG |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPP1 | up-regulates quantity by expression
transcriptional regulation
|
SOX2 |
0.328 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282549 |
|
|
Homo sapiens |
Fibroblast, Pancreatic Ductal Carcinoma Cell |
| pmid |
sentence |
| 34418441 |
The OPN/SPP1 KD CAF-CM treated cells significantly reduced the OPN/SPP1, ALDH1A1, ALDH1A3, CD44, KLF4, SOX2, OCT3/4, SOX9, BMI1, and NANOG |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPP1 | up-regulates quantity by expression
transcriptional regulation
|
SOX9 |
0.44 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282550 |
|
|
Homo sapiens |
Fibroblast, Pancreatic Ductal Carcinoma Cell |
| pmid |
sentence |
| 34418441 |
The OPN/SPP1 KD CAF-CM treated cells significantly reduced the OPN/SPP1, ALDH1A1, ALDH1A3, CD44, KLF4, SOX2, OCT3/4, SOX9, BMI1, and NANOG |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
SPP1 |
0.483 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107175 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11331591 |
In addition to osteocalcin, cbfa1 regulates expression of several other genes that are activated during osteoblast |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPP1 | up-regulates
binding
|
Av/b3 integrin |
0.638 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77910 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10835423 |
Among others, vitronectin (vn)1- (11, 13, 14) and osteopontin (opn)-coated (15-20) substrates have been shown to support cell adhesion via avb3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ALPL | down-regulates activity
dephosphorylation
|
SPP1 |
0.437 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277045 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23427088 |
This result suggests that endogenous mouse TNAP dephosphorylates OPN in osteoblasts and that overexpressed human TNAP dephosphorylates OPN, compensating for the lack of endogenous TNAP in [Col1a1-Tnap +/\u2212 ;Alpl \u2212/\u2212 ] cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
DLX5 | up-regulates quantity
transcriptional regulation
|
SPP1 |
0.369 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-245340 |
|
|
Gallus gallus |
|
| pmid |
sentence |
| 17335796 |
Dlx5 initiates a complete osteogenic differentiation in these early primary cells, by triggering Runx2, osteopontin, alkaline phosphatase, and other gene expression according to the sequential temporal sequence observed during skull osteogenesis in vivo. |
|
| Publications: |
1 |
Organism: |
Gallus Gallus |
| + |
MMP7 | up-regulates activity
cleavage
|
SPP1 |
0.72 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253321 |
|
|
|
|
| pmid |
sentence |
| 25545242 |
In this study, we found a novel motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved mouse OPN binds to α9β1 integrin. Importantly, this novel motif is involved in the development of anti-type II collagen antibody-induced arthritis (CAIA). This study provides the first in vitro and in vivo evidence that OPN cleavage by MMP-3/7 is an important regulatory mechanism for CAIA. |
|
| Publications: |
1 |
| + |
ETS2 | up-regulates quantity by expression
transcriptional regulation
|
SPP1 |
0.25 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259872 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11175361 |
We demonstrated that Ets2 is capable of binding to and transactivating the OPN promoter using gel shift and transient transfection assays |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMOC1 | up-regulates quantity by expression
transcriptional regulation
|
SPP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260385 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20359165 |
The expression of several osteoblast differentiation markers (ALP, COL1, OPN, ON, BSP and OC) was higher in SMOC1-overexpressing cells than in emptyvector-expressing cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MMP3 | up-regulates activity
cleavage
|
SPP1 |
0.684 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253320 |
|
|
|
|
| pmid |
sentence |
| 25545242 |
In this study, we found a novel motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved mouse OPN binds to α9β1 integrin. Importantly, this novel motif is involved in the development of anti-type II collagen antibody-induced arthritis (CAIA). This study provides the first in vitro and in vivo evidence that OPN cleavage by MMP-3/7 is an important regulatory mechanism for CAIA. |
|
| Publications: |
1 |
| + |
CD44 | up-regulates quantity by expression
transcriptional regulation
|
SPP1 |
0.778 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282555 |
|
|
Homo sapiens |
Fibroblast, Pancreatic Ductal Carcinoma Cell |
| pmid |
sentence |
| 34418441 |
QRT-PCR data revealed that the CD44 KD in CAF-CM treated PC cells significantly decreased mRNA expression levels of CD44, OPN/SPP1, ALDH1A1, ALDH1A3, KLF4, BMI1, and SOX2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPP1 | up-regulates activity
binding
|
A9/b1 integrin |
0.638 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253311 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24241034 |
Synovial fibroblasts and macrophages derived from arthritic joints spontaneously secreted tenascin-C and osteopontin. Synovial fibroblasts and macrophages obtained from patients with RA expressed α9β1 integrins, a common receptor for osteopontin and tenascin-C. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
SPP1
- 
- 