Summary

Name CSNK1A1
Full Name Casein kinase I isoform alpha
Synonyms CKI-alpha, CK1
Primary ID P48729
Links - -
Type protein
Relations 104
Pathways Wnt in cancer, WNT Signaling, WNT/FLT3
Function Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).

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Relations


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Regulator Mechanism target score ℹ
+ CSNK1A1up-regulates img/direct-activation.png phosphorylation CREB1 0.31
Publications: 2 Organism: Homo Sapiens
Pathways:WNT Signaling
+ CSNK1A1