| + |
MAPK3 | up-regulates 
phosphorylation
|
SP3 |
0.304 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157276 |
Ser73 |
CSKIGPPsPGDDEEE |
Homo sapiens |
|
| pmid |
sentence |
| 17685427 |
Here, we show that sp3, which, as sp1, belongs to the gc-rich binding transcription factor family, is also phosphorylated by erk in vitro on serine 73. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK1 | up-regulates
phosphorylation
|
SP3 |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157272 |
Ser73 |
CSKIGPPsPGDDEEE |
Homo sapiens |
|
| pmid |
sentence |
| 17685427 |
Here, we show that sp3, which, as sp1, belongs to the gc-rich binding transcription factor family, is also phosphorylated by erk in vitro on serine 73. in the inducible cell lines, expression of wild-type form of sp3 increases vegf production whereas the s73a form has a reduced potential reflecting its lower transcriptional activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Gbeta | up-regulates
phosphorylation
|
SP3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270053 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17685427 |
Here, we show that sp3, which, as sp1, belongs to the gc-rich binding transcription factor family, is also phosphorylated by erk in vitro on serine 73. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP3 | down-regulates quantity by repression 
transcriptional regulation
|
SOX18 |
0.288 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254820 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18496767 |
co-transfection experiments revealed that over-expression of Sp3 and ZBP-89 down-regulate, while over-expression of NF-Y up-regulates SOX18 promoter activity in HeLa cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP3 | down-regulates quantity by repression
transcriptional regulation
|
MAOB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253870 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11259630 |
Cotransfection experiments show that Sp1 and its closely related family member Sp4 can trans-activate MAO B promoter activity through the proximal cluster of Sp1 sites and its activation can be repressed by the over-expression of Sp3 and a related family member BTEB2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP1CA | down-regulates activity 
dephosphorylation
|
SP3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251953 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12684058 |
Transcription factors Sp1 and Sp3 activate alpha-ENaC2 transcription through a GC-rich element (Sp1-binding site) in the promoter. Sp1 and Sp3 are essential for alpha-ENaC2 transcription in lung epithelial cells and that dephosphorylation of the Sp transcription factors by PP1 suppresses alpha-ENaC2 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP3 | up-regulates quantity by expression
transcriptional regulation
|
ASNS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268020 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 11867623 |
Sp1 and Sp3 Activate Transcription Driven by the AS Promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP3 | up-regulates quantity by expression 
transcriptional regulation
|
IFITM5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254220 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23530031 |
Regulation of the bone-restricted IFITM-like (Bril) gene transcription by Sp and Gli family members and CpG methylation. Bril transcription is activated by Sp1, Sp3, OSX, and GLI2 and by CpG demethylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP3 | up-regulates quantity by expression
transcriptional regulation
|
FMR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255203 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15479157 |
we show that Sp1 (specificity protein 1) and Sp3 are also strong positive regulators of FMR1 promoter activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | up-regulates
phosphorylation
|
SP3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270165 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17685427 |
Here, we show that sp3, which, as sp1, belongs to the gc-rich binding transcription factor family, is also phosphorylated by erk in vitro on serine 73. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP3 | up-regulates quantity by expression
transcriptional regulation
|
SCNN1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251951 |
|
|
Homo sapiens |
Lung Epithelial Cell |
| pmid |
sentence |
| 12684058 |
Transcription factors Sp1 and Sp3 activate alpha-ENaC2 transcription through a GC-rich element (Sp1-binding site) in the promoter. Sp1 and Sp3 are essential for alpha-ENaC2 transcription in lung epithelial cells and that dephosphorylation of the Sp transcription factors by PP1 suppresses alpha-ENaC2 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP3 | up-regulates quantity by expression
transcriptional regulation
|
HGF |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251741 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9223667 |
Furthermore, in transient cotransfection assays, overexpression of Sp1 and/or Sp3 stimulated HGF promoter activity independently and additively through binding to the Sp1 binding site in the HGF gene promoter region. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PP1 | down-regulates activity
dephosphorylation
|
SP3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264652 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12684058 |
Transcription factors Sp1 and Sp3 activate alpha-ENaC2 transcription through a GC-rich element (Sp1-binding site) in the promoter. Sp1 and Sp3 are essential for alpha-ENaC2 transcription in lung epithelial cells and that dephosphorylation of the Sp transcription factors by PP1 suppresses alpha-ENaC2 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP3 | up-regulates quantity by expression
|
ITGA11 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253351 |
|
|
Homo sapiens |
HT-1080 Cell |
| pmid |
sentence |
| 16300938 |
We speculate that the "mesenchymal signature" of alpha11 integrin gene expression is controlled by the activity of Sp1/Sp3, fibroblast-specific combinations of Ets family members and yet unidentified enhancer-binding transcription factors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP3 | up-regulates quantity by expression
transcriptional regulation
|
CYP27A1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255197 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11867220 |
Therefore, Sp1, Sp3 and HNF4 co-operate in the expression of the human CYP27 gene in HepG2 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP3 | down-regulates quantity by repression
transcriptional regulation
|
LORICRIN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254537 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12200429 |
Loricrin expression is suppressed by Jun B, Sp3, and KSR-1 proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP3 | up-regulates quantity by expression
transcriptional regulation
|
PCYT1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266232 |
|
|
Drosophila melanogaster |
SCHNEIDER-2 Cell |
| pmid |
sentence |
| 10744779 |
Sp1 and Sp3 function as transcriptional activators of the Ctpct promoter |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
SP3 | up-regulates quantity by expression
transcriptional regulation
|
SLC19A3 |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255214 |
|
|
Drosophila melanogaster |
SCHNEIDER-2 Cell |
| pmid |
sentence |
| 15217784 |
In transiently transfected Drosophila SL2 cells, both SP1 and SP3 transactivated the SLC19A3 minimal promoter in a dose-dependent manner and in combination demonstrated an additive stimulatory effect. |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
SP3 | up-regulates quantity by expression
transcriptional regulation
|
CBS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254813 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12427542 |
We previously described essential transactivating roles for specificity protein 1 (Sp1), Sp3, nuclear factor Y (NF-Y), and USF-1 in the regulation of the CBS-1b promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP3 | up-regulates quantity by expression
transcriptional regulation
|
KLK3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253665 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 15708372 |
We characterized four Sp1/Sp3 binding sites in the proximal promoter of the PSA gene. In a luciferase assay, these sites contributed to the basal promoter activity in prostate cancer cells. In an electrophoretic mobility shift assay and chromatin immunoprecipitation assay, we confirmed that Sp1 and Sp3 bind to these sites. Overexpression of wild-type Sp1 and Sp3 further upregulated the promoter activity, whereas overexpression of the Sp1 dominant-negative form or addition of mithramycin A significantly reduced the promoter activity and the endogenous mRNA level of PSA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP3 | up-regulates quantity by expression
transcriptional regulation
|
CADM1 |
0.273 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268959 |
|
|
|
|
| pmid |
sentence |
| 18794147 |
Treatment with mithramycin A, an inhibitor of Sp1 or Sp3 binding, resulted in reduction of Cadm1 gene expression, therefore suggesting a potential role of Sp1/Sp3 in Cadm1 regulation. |
|
| Publications: |
1 |
| + |
SP3 | up-regulates quantity by expression
transcriptional regulation
|
SLC9A3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254271 |
|
|
Drosophila melanogaster |
SCHNEIDER-2 Cell |
| pmid |
sentence |
| 16464174 |
Co-transfection of Sp1 or Sp3 into SL2 cells activated the NHE3-reporter constructs, suggesting that Sp1 and Sp3 act as positive regulators of the NHE3 expression. In addition, overexpression of EGR-1 was sufficient to transactivate the NHE3-reporter gene activity |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
3.0
SP3
- 
- 