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Summary
Name
TDO2
Full Name
Tryptophan 2,3-dioxygenase
Synonyms
TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase | TDO
Primary ID
P48775
Links
-
-
Type
protein
Relations
2
Function
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
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by mechanism
none
transcriptional regulation
by effect
none
down-regulates quantity by repression
by organism:
none
by tissue:
none
by cell-line
none
hepatocyte
Relations
Regulator
Mechanism
target
score
ℹ
+
GATA4
down-regulates quantity by repression
transcriptional regulation
TDO2
0.255
Identifier
Residue
Sequence
Organism
Cell Line
SIGNOR-268994
Hepatocyte
pmid
sentence
19003156
GATA4 inhibits expression of the tryptophan oxygenase gene by binding to the TATA box in fetal hepatocytes.
Publications:
1
+
NR3C1
down-regulates quantity by repression
transcriptional regulation
TDO2
0.345
Identifier
Residue
Sequence
Organism
Cell Line
SIGNOR-268995
pmid
sentence
16272140
Repression of GR-mediated expression of the tryptophan oxygenase gene by the SWI/SNF complex during liver development.
Publications:
1