4.0
Summary
| Name |  SLC11A1View Modifications |
| Full Name | Natural resistance-associated macrophage protein 1 |
| Synonyms | NRAMP 1, Solute carrier family 11 member 1 | LSH, NRAMP, NRAMP1 |
| Primary ID | P49279 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SRC | up-regulates activity 
phosphorylation
|
SLC11A1 | 0.28 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | IFNG | up-regulates 
|
SLC11A1 | 0.348 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SLC11A1 | up-regulates
|
M1_polarization | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PAMPs | up-regulates
|
SLC11A1 | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |