Name	SLC11A1 View Modifications
Full Name	Natural resistance-associated macrophage protein 1
Synonyms	NRAMP 1, Solute carrier family 11 member 1 \| LSH, NRAMP, NRAMP1
Primary ID	P49279
Links	- -
Type	protein
Relations	4
Function	Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.