Summary

Name MCM2
Full Name DNA replication licensing factor MCM2
Synonyms Minichromosome maintenance protein 2 homolog, Nuclear protein BM28 | BM28, CCNL1, CDCL1, KIAA0030
Primary ID P49736
Links - -
Type protein
Relations 19
Function Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ CDC7up-regulates img/direct-activation.png phosphorylation MCM2 0.96
Publications: 11 Organism: Homo Sapiens
+ ATR img/unknown.png phosphorylation MCM2 0.696
Publications: 1 Organism: Homo Sapiens
+ CSNK2A1up-regulates img/direct-activation.png phosphorylation MCM2 0.263
Publications: 1 Organism: Homo Sapiens
+ CDK2up-regulates img/direct-activation.png phosphorylation MCM2 0.722
Publications: 1 Organism: Homo Sapiens
+ CDK7up-regulates activity img/direct-activation.png phosphorylation MCM2 0.307
Publications: 3 Organism: Homo Sapiens
+ CDT1up-regulates activity img/direct-activation.png binding MCM2 0.806
Publications: 1 Organism: Homo Sapiens
+ MCM2form complex img/form-complex.png binding MCM 0.76
Publications: 1 Organism: Homo Sapiens