3.0
Summary
| Name |  CASP6View Modifications |
| Full Name | Caspase-6 |
| Synonyms | CASP-6, Apoptotic protease Mch-2 | MCH2 |
| Primary ID | P55212 |
| Links |  -  -  |
| Type | protein |
| Relations | 16 |
| Pathways | COVID-19 Causal Network, SARS-COV APOPTOSIS |
| Function | Cysteine protease that plays essential roles in programmed cell death, axonal degeneration, development and innate immunity (PubMed:8663580, PubMed:32298652). During apoptosis, localizes in the nucleus and cleaves the nuclear structural protein NUMA1 and lamin A/LMNA thereby inducing nuclear shrinkage and fragmentation (PubMed:17401638, PubMed:8663580, PubMed:9463409). Furthermore, cleaves many transcription factors such as NF-kappa-B and cAMP response element-binding protein/CREBBP (PubMed:10559921, PubMed:14657026). Plays an essential role in axon degeneration during axon pruning which is the remodeling of axons during neurogenesis but not apoptosis (By similarity). Regulates B-cell programs both during early development and after antigen stimulation (By similarity). In addition, promotes the ZBP1-mediated activation of programmed cell death pathways including pyroptosis, apoptosis, and necroptosis (PANoptosis) and plays an essential role in defense against viruses (PubMed:32298652). Mechanistically, interacts with RIPK3 and enhances the interaction between RIPK3 and ZBP1, leading to ZBP1-mediated inflammasome activation and cell death (PubMed:32298652). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CASP6 | up-regulates activity 
cleavage
|
PSEN2 | 0.37 |
| Publications: | 2 | Organism: | In Vitro | |
| + | CASP6 | up-regulates activity
cleavage
|
PSEN1 | 0.379 |
| Publications: | 2 | Organism: | In Vitro | |
| + | CASP6 | up-regulates activity
cleavage
|
N | 0.2 |
| Publications: | 2 | Organism: | Chlorocebus Aethiops | |
| Pathways: | COVID-19 Causal Network, SARS-COV APOPTOSIS | |||
| + | CASP6 | up-regulates activity
cleavage
|
APP | 0.712 |
| Publications: | 1 | Organism: | In Vitro | |
| + | NUAK1 | down-regulates activity 
phosphorylation
|
CASP6 | 0.497 |
| Publications: | 1 | Organism: | In Vitro | |
| + | CASP8 | up-regulates
cleavage
|
CASP6 | 0.722 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, SARS-COV APOPTOSIS | |||
| + | CASP6 | form complex 
binding
|
Caspase 6 complex | 0.2 |
| Publications: | 2 | |||
| + | CASP6 | down-regulates
cleavage
|
LMNA | 0.648 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CASP3 | up-regulates
cleavage
|
CASP6 | 0.601 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, SARS-COV APOPTOSIS | |||
| + | Caspase 3 complex | up-regulates
cleavage
|
CASP6 | 0.601 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Caspase 8 complex | up-regulates
cleavage
|
CASP6 | 0.722 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CASP6 | up-regulates
cleavage
|
CASP8 | 0.722 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, SARS-COV APOPTOSIS | |||