| + |
HCFC1 | up-regulates activity 
binding
|
Set1-Ash2 HMT complex |
0.763 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264481 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12670868 |
Our analysis of HCF-1-associated proteins suggests that a K4 histone H3 HMT complex has been conserved from yeast to humans in both structure and activity: the Set1/Ash2 HMT. The results presented here show that this Set1/Ash2 HMT complex, in mutually exclusive interactions, can associate with HCF-1 bound to the repressive Sin3 HDAC or the transcriptional activator VP16, indicating a diversity of transcriptional regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HCFC1 | form complex 
binding
|
NSL histone acetyltransferase |
0.587 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267165 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20018852 |
Here we report an analysis of the subunit composition and substrate specificity of the NSL complex. Proteomic analyses of complexes purified through multiple candidate subunits reveal that NSL is composed of nine subunits. Two of its subunits, WD repeat domain 5 (WDR5) and host cell factor 1 (HCF1), are shared with members of the MLL/SET family of histone H3 lysine 4 (H3K4) methyltransferase complexes, and a third subunit, MCRS1, is shared with the human INO80 chromatin-remodeling complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HCFC1 | up-regulates activity
binding
|
CREB3 |
0.583 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241372 |
|
|
in vitro |
|
| pmid |
sentence |
| 9658067 |
We also show that while interaction with HCF is not required for the ability of Luman to activate transcription when tethered to the GAL4 promoter, it appears to be essential for Luman to activate transcription through CRE sites. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
HCFC1 | down-regulates activity 
binding
|
ZBTB17 |
0.35 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-223590 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 12244100 |
We show here that HCF-1 directly binds to the Myc-interacting protein Miz-1. HCF-1 Represses Gal4-Miz-1-mediated Transcriptional Activation |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
GABPB1 | down-regulates activity
binding
|
HCFC1 |
0.334 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-221377 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10675337 |
The C1 factor interacts with the GABP_ transactivation domain.The domain of the C1 factor required for C1GABP interaction can inhibit GABP_dependent transcriptional activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GABPB2 | down-regulates activity
binding
|
HCFC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-221318 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10675337 |
The C1 factor interacts with the GABP_ transactivation domain.The domain of the C1 factor required for C1GABP interaction can inhibit GABP_dependent transcriptional activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
HCFC1
- 
- 