| + |
AFF2 | up-regulates activity 
binding
|
P-TEFb |
0.401 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266801 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17135274 |
Af4 associates with P-TEFb and stimulates its kinase activity. P-TEFb also phosphorylates AF4 which down-regulates its transactivation activity, providing a negative feedback mechanism for the control of P-TEFb elongation activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AFF2 | up-regulates activity
binding
|
RNA Polymerase II |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266797 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17135274 |
Here, we provide the first evidence for a direct role of AF4 in the regulation of transcriptional elongation by RNA polymerase II (Pol II). We demonstrate that mouse Af4 functions as a positive regulator of Pol II transcription elongation factor b (P-TEFb) kinase and, in complex with MLL fusion partners Af9, Enl and Af10, as a mediator of histone H3-K79 methylation by recruiting Dot1 to elongating Pol II. These pathways are interconnected and tightly regulated by the P-TEFb-dependent phosphorylation of Af4, Af9 and Enl which controls their transactivation activity and/or protein stability. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
P-TEFb | down-regulates quantity by destabilization 
phosphorylation
|
AFF2 |
0.401 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266798 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17135274 |
P-TEFb phosphorylates Af4 and down-regulates its transactivation activity. P-TEFb also phosphorylates AF4 which down-regulates its transactivation activity, providing a negative feedback mechanism for the control of P-TEFb elongation activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
AFF2
- 
- 