Summary

Name EFNA5
Full Name Ephrin-A5
Synonyms AL-1, EPH-related receptor tyrosine kinase ligand 7, LERK-7 | EPLG7, LERK7
Primary ID P52803
Links - -
Type protein
Relations 5
Function Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding EPHA2 0.66
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA3 0.79
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA5 0.96
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA4 0.95
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA8 0.91
Publications: 1 Organism: Homo Sapiens