Relation Results

Summary

Name EPHA3
Full Name Ephrin type-A receptor 3
Synonyms EPH-like kinase 4, EK4, hEK4, HEK, Human embryo kinase, Tyrosine-protein kinase TYRO4, Tyrosine-protein kinase receptor ETK1, Eph-like tyrosine kinase 1 | ETK, ETK1, HEK, TYRO4
Primary ID P29320
Links - -
Type protein
Relations 10
Function Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidir ...
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Type: Score: Layout: SPV 
0.20.4260.9420.5080.6110.7960.81EPHA3PTPN1EFNA5SRCCRKEFNA3EFNA1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ EPHA3up-regulates activity img/direct-activation.png phosphorylation EPHA3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-251115 Tyr596 KLPGLRTyVDPHTYE Homo sapiens
pmid sentence
Eph receptor activation leads to tyrosine phosphorylation of three major autophosphorylation sites. these residues function to regulate kinase activity, their phosphorylation being required for full intrinsic enzyme activity. these tyrosines (EphA3 Y596, Y602 and Y779) as the prominent autophosphorylation sites of EphA3
Identifier Residue Sequence Organism Cell Line
SIGNOR-251116 Tyr602 TYVDPHTyEDPTQAV Homo sapiens
pmid sentence
Eph receptor activation leads to tyrosine phosphorylation of three major autophosphorylation sites. these residues function to regulate kinase activity, their phosphorylation being required for full intrinsic enzyme activity. these tyrosines (EphA3 Y596, Y602 and Y779) as the prominent autophosphorylation sites of EphA3
Identifier Residue Sequence Organism Cell Line
SIGNOR-251117 Tyr779 EDDPEAAyTTRGGKI Homo sapiens
pmid sentence
Eph receptor activation leads to tyrosine phosphorylation of three major autophosphorylation sites. these residues function to regulate kinase activity, their phosphorylation being required for full intrinsic enzyme activity. these tyrosines (EphA3 Y596, Y602 and Y779) as the prominent autophosphorylation sites of EphA3
Publications: 3 Organism: Homo Sapiens
+ PTPN1down-regulates activity img/direct_inhibition.png dephosphorylation EPHA3 0.426
Identifier Residue Sequence Organism Cell Line
SIGNOR-248426 Tyr779 EDDPEAAyTTRGGKI Homo sapiens
pmid sentence
Nevertheless, the finding that phosphorylation of the activation loop tyrosine (EphA3-Y779), a recently identified PTP1B substrate (Mertins et al., 2008), is essential for ligand-induced endocytosis (Janes et al., 2009)
Publications: 1 Organism: Homo Sapiens
+ EFNA5up-regulates img/direct-activation.png binding EPHA3 0.942
Identifier Residue Sequence Organism Cell Line
SIGNOR-52470 Homo sapiens
pmid sentence
Highly promiscuous for ephrin-a ligands it binds preferentially efna5 and became active.
Publications: 1 Organism: Homo Sapiens
+ EPHA3up-regulates img/direct-activation.png binding SRC 0.508
Identifier Residue Sequence Organism Cell Line
SIGNOR-58139 Homo sapiens Neuron
pmid sentence
We propose src kinase as a downstream effector that mediates the neuron's response to eph receptor activation.
Publications: 1 Organism: Homo Sapiens
+ EPHA3up-regulates img/direct-activation.png binding CRK 0.611
Identifier Residue Sequence Organism Cell Line
SIGNOR-115335 Homo sapiens HEK-293 Cell
pmid sentence
Our results suggest that recruitment of crkii and activation of rho signalling are responsible for epha3-mediated cell rounding, blebbing and de-adhesion, and that ephrin-a5-mediated receptor clustering and epha3 tyrosine kinase activity are essential for this response
Publications: 1 Organism: Homo Sapiens
+ EFNA3up-regulates img/direct-activation.png binding EPHA3 0.796
Identifier Residue Sequence Organism Cell Line
SIGNOR-52312 Homo sapiens
pmid sentence
The activation of eph receptors by their ligands, which are membrane-anchored molecules, involves a cell-cell recognition event that often causes cell repulsion. transmembrane ligands for eph receptors also exhibit properties of signal transducing molecules, suggesting that bidirectional signaling occurs when receptor-expressing cells contact ligand-expressing cells.
Publications: 1 Organism: Homo Sapiens
+ EFNA1up-regulates img/direct-activation.png binding EPHA3 0.81
Identifier Residue Sequence Organism Cell Line
SIGNOR-52005 Homo sapiens
pmid sentence
Transmembrane ligands for eph receptors also exhibit properties of signal transducing molecules, suggesting that bidirectional signaling occurs when receptor-expressing cells contact ligand-expressing cells.
Identifier Residue Sequence Organism Cell Line
SIGNOR-56904 Homo sapiens
pmid sentence
Ephrin-a1 binds and activates the tyrosine kinase activity of eph-a2, and has a dissociation constant of 20_30 nm. ephrin-a1 interacts with all the other epha subclass receptors as well, although with different affinity
Publications: 2 Organism: Homo Sapiens
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