Summary

Name EPHB1
Full Name Ephrin type-B receptor 1
Synonyms ELK, EPH tyrosine kinase 2, EPH-like kinase 6, EK6, hEK6, Neuronally-expressed EPH-related tyrosine kinase, NET, Tyrosine-protein kinase receptor EPH-2 | ELK, EPHT2, HEK6, NET
Primary ID P54762
Links - -
Type protein
Relations 8
Function Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ EPHB1up-regulates activity img/direct-activation.png phosphorylation NRCAM 0.423
Publications: 1 Organism: Homo Sapiens
+ EPHB1up-regulates activity img/direct-activation.png phosphorylation CASKIN1 0.287
Publications: 2 Organism: Chlorocebus Aethiops
+ EPHB1up-regulates activity img/direct-activation.png phosphorylation EPHB1 0.2
Publications: 2 Organism: Cricetulus Griseus
+ EPHB1up-regulates activity img/direct-activation.png relocalization MAP2K4 0.2
Publications: 1
+ CNKSR1up-regulates activity img/direct-activation.png binding EPHB1 0.297
Publications: 1
+ EFNB1up-regulates img/direct-activation.png binding EPHB1 0.822
Publications: 1 Organism: Homo Sapiens