Relation Results

Summary

Name CNKSR1
Full Name Connector enhancer of kinase suppressor of ras 1
Synonyms Connector enhancer of KSR 1, CNK homolog protein 1, CNK1, hCNK1, Connector enhancer of KSR-like | CNK1
Primary ID Q969H4
Links - -
Type protein
Relations 6
Function May function as an adapter protein or regulator of Ras signaling pathways.

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Type: Score: Layout: SPV 
0.4860.4110.2970.699SRCCNKSR1RASSF1EPHB1RAF1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ SRCup-regulates activity img/direct-activation.png phosphorylation CNKSR1 0.486
Identifier Residue Sequence Organism Cell Line
SIGNOR-275919 Tyr26 LDDSLQDyPFEDWQL
pmid sentence
We identified Tyr 26 as a PDGF-induced and, additionally, Tyr 519 and Tyr 665 as SRC-induced tyrosine phosphorylation sites. Phosphomimetic mutants indicate that phosphorylation of Tyr 519 recruits CNK1 to the nucleus and additional phosphorylation of Tyr 26 enables CNK1 to promote SRE-dependent gene expression.
Identifier Residue Sequence Organism Cell Line
SIGNOR-275918 Tyr519 PPREEDCySETEAED
pmid sentence
We identified Tyr 26 as a PDGF-induced and, additionally, Tyr 519 and Tyr 665 as SRC-induced tyrosine phosphorylation sites. Phosphomimetic mutants indicate that phosphorylation of Tyr 519 recruits CNK1 to the nucleus and additional phosphorylation of Tyr 26 enables CNK1 to promote SRE-dependent gene expression.
Identifier Residue Sequence Organism Cell Line
SIGNOR-275920 Tyr665 KEQNRELySEGLGAW
pmid sentence
We identified Tyr 26 as a PDGF-induced and, additionally, Tyr 519 and Tyr 665 as SRC-induced tyrosine phosphorylation sites. Phosphomimetic mutants indicate that phosphorylation of Tyr 519 recruits CNK1 to the nucleus and additional phosphorylation of Tyr 26 enables CNK1 to promote SRE-dependent gene expression.
Publications: 3
+ CNKSR1up-regulates img/direct-activation.png binding RASSF1 0.411
Identifier Residue Sequence Organism Cell Line
SIGNOR-198432 Homo sapiens
pmid sentence
Cnk1 binds to rassf1a and promotes apoptosis through a pathway that requires rassf1a and mst kinases.
Publications: 1 Organism: Homo Sapiens
+ CNKSR1up-regulates activity img/direct-activation.png binding EPHB1 0.297
Identifier Residue Sequence Organism Cell Line
SIGNOR-275921
pmid sentence
The phosphorylated CNK1 interacts with ephrinB1. The binding of ephrinB1 to CNK1 connects RhoA and p115RhoGEF with ephrinB1-associated MKK4, promoting JNK activation and cell migration.
Publications: 1
+ CNKSR1up-regulates img/direct-activation.png binding RAF1 0.699
Identifier Residue Sequence Organism Cell Line
SIGNOR-135674 Homo sapiens
pmid sentence
Here we demonstrate that the connector enhancer of ksr1, cnk1, mediates src-dependent tyrosine phosphorylation and activation of raf-1. Cnk1 binds preactivated raf-1 and activated src and forms a trimeric complex.
Publications: 1 Organism: Homo Sapiens
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