| + |
PRKCG |
phosphorylation
|
STXBP1 |
0.394 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249184 |
Ser306 |
VSQEVTRsLKDFSSS |
in vitro |
|
| pmid |
sentence |
| 12519779 |
Munc18a is essential for neurotransmitter release by exocytosis and can be phosphorylated by PKC in vitro on Ser-306 and Ser-313. We demonstrate that it is phosphorylated on Ser-313 in response to phorbol ester treatment in adrenal chromaffin cells. Mutation of both phosphorylation sites to glutamate reduces its affinity for syntaxin and so acts as a phosphomimetic mutation. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PRKCB |
phosphorylation
|
STXBP1 |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249183 |
Ser306 |
VSQEVTRsLKDFSSS |
in vitro |
|
| pmid |
sentence |
| 12519779 |
Munc18a is essential for neurotransmitter release by exocytosis and can be phosphorylated by PKC in vitro on Ser-306 and Ser-313. We demonstrate that it is phosphorylated on Ser-313 in response to phorbol ester treatment in adrenal chromaffin cells. Mutation of both phosphorylation sites to glutamate reduces its affinity for syntaxin and so acts as a phosphomimetic mutation. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PRKCA |
phosphorylation
|
STXBP1 |
0.386 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249182 |
Ser306 |
VSQEVTRsLKDFSSS |
in vitro |
|
| pmid |
sentence |
| 12519779 |
Munc18a is essential for neurotransmitter release by exocytosis and can be phosphorylated by PKC in vitro on Ser-306 and Ser-313. We demonstrate that it is phosphorylated on Ser-313 in response to phorbol ester treatment in adrenal chromaffin cells. Mutation of both phosphorylation sites to glutamate reduces its affinity for syntaxin and so acts as a phosphomimetic mutation. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PRKCG | down-regulates activity 
phosphorylation
|
STXBP1 |
0.394 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249187 |
Ser313 |
SLKDFSSsKRMNTGE |
Bos taurus |
Chromaffin Cell |
| pmid |
sentence |
| 12519779 |
Munc18a is essential for neurotransmitter release by exocytosis and can be phosphorylated by PKC in vitro on Ser-306 and Ser-313. We demonstrate that it is phosphorylated on Ser-313 in response to phorbol ester treatment in adrenal chromaffin cells. Mutation of both phosphorylation sites to glutamate reduces its affinity for syntaxin and so acts as a phosphomimetic mutation. |
|
| Publications: |
1 |
Organism: |
Bos Taurus |
| + |
PRKCB | down-regulates activity
phosphorylation
|
STXBP1 |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249186 |
Ser313 |
SLKDFSSsKRMNTGE |
Bos taurus |
Chromaffin Cell |
| pmid |
sentence |
| 12519779 |
Munc18a is essential for neurotransmitter release by exocytosis and can be phosphorylated by PKC in vitro on Ser-306 and Ser-313. We demonstrate that it is phosphorylated on Ser-313 in response to phorbol ester treatment in adrenal chromaffin cells. Mutation of both phosphorylation sites to glutamate reduces its affinity for syntaxin and so acts as a phosphomimetic mutation. |
|
| Publications: |
1 |
Organism: |
Bos Taurus |
| + |
STXBP1 | up-regulates activity 
binding
|
STX1A |
0.919 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264042 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 9395480 |
Munc18-1 is a neuronal protein that interacts with syntaxin 1 and is required for synaptic vesicle exocytosis. We have now identified two Munc18-1-interacting proteins called Mint1 and Mint2 that may mediate the function of Munc18-1. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Neurotransmitters release |
| + |
APBA3 | up-regulates activity
binding
|
STXBP1 |
0.48 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264036 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 9395480 |
Munc18-1 is a neuronal protein that interacts with syntaxin 1 and is required for synaptic vesicle exocytosis. We have now identified two Munc18-1-interacting proteins called Mint1 and Mint2 that may mediate the function of Munc18-1. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
APBA2 | up-regulates activity
binding
|
STXBP1 |
0.689 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264037 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 9395480 |
Munc18-1 is a neuronal protein that interacts with syntaxin 1 and is required for synaptic vesicle exocytosis. We have now identified two Munc18-1-interacting proteins called Mint1 and Mint2 that may mediate the function of Munc18-1. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Tissue: |
Brain |
| + |
APBA1 | up-regulates activity
binding
|
STXBP1 |
0.689 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264035 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 9395480 |
Munc18-1 is a neuronal protein that interacts with syntaxin 1 and is required for synaptic vesicle exocytosis. We have now identified two Munc18-1-interacting proteins called Mint1 and Mint2 that may mediate the function of Munc18-1. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Neurotransmitters release |
| + |
STXBP1 | up-regulates activity
transcriptional regulation
|
SNARE_complex |
0.835 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263970 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 30267828 |
In neuronal exocytosis, Munc18-1 (aSM-protein) and Munc13-1/2 (similar to CATCHRs) arethe relevant proteins responsible for SNARE-complex formation. Munc18-1 associates with syntaxin-1 in its‘closed’ conformation, i.e. with the regulatory Habc-domain folded against the SNARE (H3-)-domain. Opening-up of syntaxin is catalyzed by the Mun-domainwithin Munc13-1/2 and allows assembly with the partnerSNARE SNAP-25 and possibly VAMP2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Neurotransmitters release |
| + |
STXBP1 | up-regulates activity
binding
|
NRXN1 |
0.507 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264040 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 11036064 |
We propose that all these neurexin complexes can interact with Munc18. Both Mint1 and Mint2 could function as direct adaptors of Munc18 to neurexins, whereas Mint1 in addition could recruit Munc18 to CASK-neurexin (Fig. 5 B). |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | Neurotransmitters release |
3.0
STXBP1
- 
- 