MTOR Signaling

Pathway ID: SIGNOR-MSView in NDEx

Description: The mammalian target of rapamycin (mTOR) signaling pathway couples energy and nutrient abundance to cellular growth. mTor is serine/threonine kinase acting in two complexes (mTORC1 and mTORC2) which exert their actions by regulating other important kinases, such as S6K and Akt. In particular, mTORC1 integrates multiple signals reflecting nutrients' availability or deprivation promoting cellular growth or catabolic processes respectively.

complexity level

level 1 seed interactions
level 2 connect
level 3 first neighbors
level 4 all
level 5 PPI

34 Seed Entities

Organism:
Name Primary ID
EIF4EBP1 Q13541
MTOR P42345
LAMTOR SIGNOR-C26
AMPK SIGNOR-C15
PTEN P60484
AKT1S1 Q96B36
Lipogenesis SIGNOR-PH30
TSC1/TSC2 SIGNOR-C101
PIK3R1 P27986
IRS1 P35568
ULK1 O75385
PPARGC1A Q9UBK2
PPARG P37231
PDPK1 O15530
AKT SIGNOR-PF24
mTORC2 SIGNOR-C2
RPTOR Q8N122
RHEB Q15382
GSK3B P49841
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate CHEBI:16618
TFEB P19484
RAGAC SIGNOR-C113
mitochondrial biogenesis SIGNOR-PH32
Protein Synthesis SIGNOR-PH29
EIF4E P06730
INSR P06213
RPS6KB1 P23443
RPS6 P62753
INS P01308
AminoAcids SIGNOR-ST5
PIK3CA P42336
RPS6KA1 Q15418
ERK1/2 SIGNOR-PF1
SREBF1 P36956