MTOR Signaling

Pathway ID: SIGNOR-MSView in NDEx

Description: The mammalian target of rapamycin (mTOR) signaling pathway couples energy and nutrient abundance to cellular growth. mTor is serine/threonine kinase acting in two complexes (mTORC1 and mTORC2) which exert their actions by regulating other important kinases, such as S6K and Akt. In particular, mTORC1 integrates multiple signals reflecting nutrients' availability or deprivation promoting cellular growth or catabolic processes respectively.

34 Seed Entities

Organism:
Name Primary ID
RPS6KA1 Q15418
SREBF1 P36956
LAMTOR SIGNOR-C26
MTOR P42345
TSC SIGNOR-C101
RPTOR Q8N122
AMPK SIGNOR-C15
Lipogenesis SIGNOR-PH30
INSR P06213
RPS6KB1 P23443
RHEB Q15382
EIF4EBP1 Q13541
ERK1/2 SIGNOR-PF1
INS P01308
Mitochondrial_biogenesis SIGNOR-PH32
AKT SIGNOR-PF24
AminoAcids SIGNOR-ST5
PTEN P60484
RPS6 P62753
TFEB P19484
PIK3R1 P27986
PPARGC1A Q9UBK2
RAGAC SIGNOR-C113
mTORC2 SIGNOR-C2
PDPK1 O15530
AKT1S1 Q96B36
PPARG P37231
PIK3CA P42336
EIF4E P06730
PIP3 CHEBI:16618
Protein_synthesis SIGNOR-PH29
IRS1 P35568
GSK3B P49841
ULK1 O75385